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Experiments were performed in animals to evaluate 4,5,6,7-tetrachloro-2-(2 dimethylaminoethyl)-isoindoline dimethochloride, (Su-3088), as an orally effective ganglion blocking drug. These demonstrated reduction of blood pressure, suppression of vasopressor reflexes and potentiation of the pressor action of epinephrine. Neostigmine deblocked drug effects and(More)
Rats were exposed to a hyperthermal environment or 1600 MHz radiation for 10 minutes to achieve equivalent rectal temperature increase (4 degrees C). Brain areas were quantitatively assayed for changes in magnesium, calcium, copper, zinc, iron, sodium, and potassium. Iron was increased in several brain regions of both hyperthermal and irradiated animals.(More)
Values of inhibition constants, Ki, for a family of structurally related, competitive inhibitors of calf spleen purine nucleoside phosphorylase (PNP) have been determined employing both inosine as substrate and a manual assay and 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG) as substrate and a robot-based enzyme kinetics facility. Several of the(More)
  • A W Boddie, K Wright, +5 authors R G Martin
  • 1986
In a V-2 model of solitary hepatic metastasis, residual tumor was histologically identified in the treatment field in only three of 14 (21%) animals subjected to microsphere embolization of tumor arterioles plus focal (43 degrees C, 40 min) hyperthermia compared with seven of ten (70%) subjected to focal (43 degrees C, 40 min) hyperthermia alone (P less(More)
A novel three-element radiofrequency hyperthermia system, consisting of paired multiple-feed inductors positioned between two large capacitor plates and a moveable grounding point, was designed and constructed. The spatial orientation of these elements and the phase of the current flowing through them can be varied to produce asymmetric magnetic field(More)
Critical modifications have been made in the grounded elements of a previously reported hybrid radiofrequency heating system with inductive, capacitive, and grounded elements designed for deep focal heating. These modifications facilitate introduction of the ground probe, the single invasive element of the system, into animals and humans. The modified(More)
Though MR spectroscopy has long been used to analyze the structure of organic compounds in solution, interest in applying it to the study of biologic systems has been slow in evolving because of past problems with spectral resolution in solids and gels. Renewed interest in this area has been stimulated both by the rapid growth of MR imaging as a clinical(More)
Microwave devices have been developed for rapidly inactivating brain enzymes by focusing the power output into the heads of small laboratory animals. The rapid inactivation achieved prevents postmortem changes and permits the measurement of neurochemicals such as acetylcholine at concentrations close to those obtained in vivo. The technique promises the(More)