Jack W. Frazer

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Experiments were performed in animals to evaluate 4,5,6,7-tetrachloro-2-(2 dimethylaminoethyl)isoindoline dimethochloride, (Su-3088), as an orally effective ganglion blocking drug. These demonstrated reduction of blood pressure, suppression of vasopressor reflexes and potentiation of the pressor action of epinephrine. Neostigmine deblocked drug effects and(More)
Rats were exposed to a hyperthermal environment or 1600 MHz radiation for 10 minutes to achieve equivalent rectal temperature increase (4 degrees C). Brain areas were quantitatively assayed for changes in magnesium, calcium, copper, zinc, iron, sodium, and potassium. Iron was increased in several brain regions of both hyperthermal and irradiated animals.(More)
Values of inhibition constants, Ki, for a family of structurally related, competitive inhibitors of calf spleen purine nucleoside phosphorylase (PNP) have been determined employing both inosine as substrate and a manual assay and 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG) as substrate and a robot-based enzyme kinetics facility. Several of the(More)
Microwave devices have been developed for rapidly inactivating brain enzymes by focusing the power output into the heads of small laboratory animals. The rapid inactivation achieved prevents postmortem changes and permits the measurement of neurochemicals such as acetylcholine at concentrations close to those obtained in vivo. The technique promises the(More)
Mice were sacrificed by either microwave inactivation of brain enzymes or by cervical dislocation. The norepinephrine, serotonin, 5-hydroxyindoleacetic acid and homovanillic acid content of the brains of the irradiated animals was significantly greater than that of the conventionally sacrificed controls.