Jack T. Nguyen
Highly Influential Citations15
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Allosteric regulation of proteins by conformational change is a primary means of biological control. Traditionally it has been difficult to identify and characterize novel allosteric sites and… Continue Reading
Apoptosis plays a pivotal role in the cytotoxic activity of most chemotherapeutic drugs, and defects in this pathway provide a basis for drug resistance in many cancers. Thus the ability to restore… Continue Reading
To elucidate the relationship between amyloid fibril formation in Alzheimer disease (AD) and the primary structure of the β-amyloid protein (β-AP), we investigated the ability of peptides sharing… Continue Reading
Two recent landmark structures of Src family kinases reveal how a sensitive conformational switch can be built with SH2 and SH3 domains.
Caspases are cysteine proteases and potent inducers of apoptosis. Their activation and activity is therefore tightly regulated. There are several mechanisms by which caspases can be activated but one… Continue Reading