Jack M. Heintze

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the most interesting cell types will be those that drive the continued growth of each organ A new study has identified previously uncharacterized cell populations in whole-kidney marrow from zebrafish using droplet-based, single-cell RNA sequencing. As haematopoesis occurs in the kidney marrow of adult zebrafish, this work by David Langenau, Iain Drummond(More)
DNA methylation is a key regulator of transcription, but how changes in methylation relate to altered kidney function is not well understood. Now, Anna Köttgen and colleagues identify epigenetic signatures associated with reduced estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD) in an epigenome-wide association study (EWAS) that(More)
resistant nephrotic syndrome (SRNS) are poorly understood. Now, Shazia Ashraf, Friedhelm Hildebrandt and colleagues delineate a novel pathogenic axis that links loss of function of the actin-binding protein advillin (AVIL) to the role of the established SRNS protein phospholipase Cε1 (PLCε1). Previously, the researchers found that causative single-gene(More)
The mechanisms that cause focal segmental glomerulosclerosis (FSGS) are complex and only partially understood. FSGS lesions are often observed in patients with hypertension, but the mechanisms that link high blood pressure to glomerular lesions are unclear. A new study now shows that endothelial Epas1 deficiency alters local renal haemodynamics in response(More)
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