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Although there are many algorithms available in the literature aimed at segmentation and model reconstruction of 3D angiographic images, many are focused on characterizing only a part of the vascular network. This study is motivated by the recent emerging prospects of whole-organ simulations in coronary hemodynamics, autoregulation and tissue oxygen(More)
Diabetic retinopathy is a major cause of blindness. Proliferative diabetic retinopathy is a result of severe vascular complication and is visible as neovascularization of the retina. Automatic detection of such new vessels would be useful for the severity grading of diabetic retinopathy, and it is an important part of screening process to identify those who(More)
Cubic Hermite meshes provide an efficient representation of anatomy, and are useful for simulating soft tissue mechanics. However, their personalization can be a complex, time consuming and labour-intensive process. This paper presents a method based on image registration and using an existing template for deriving a patient-specific cubic Hermite mesh. Its(More)
Experimental data and advanced imaging techniques are increasingly enabling the extraction of detailed vascular anatomy from biological tissues. Incorporation of anatomical data within perfusion models is non-trivial, due to heterogeneous vessel density and disparate radii scales. Furthermore, previous idealised networks have assumed a spatially repeating(More)
There is a need for, and utility in, the acquisition of data sets of cardiac histoanatomy, with the vision of reconstructing individual hearts on the basis of noninvasive imaging, such as MRI, enriched by reference to detailed atlases of serial histology obtained from representative samples. These data sets would be useful not only as a repository of(More)
In this study, we review the development and application of multi-physics and multi-scale coupling in the construction of whole-heart physiological models. Through an examination of recent computational modelling developments, we analyse the significance of coupling mechanisms for the increased understanding of cardiac function in the areas of(More)
Coronary flow is governed by a number of determinants including network anatomy, systemic afterload and the mechanical interaction with the myocardium throughout the cardiac cycle. The range of spatial scales and multi-physics nature of coronary perfusion highlights a need for a multiscale framework that captures the relevant details at each level of the(More)
The Hodgkin-Huxley formalism for quantitative characterization of ionic channels is widely used in cellular electrophysiological models. Model parameters for these individual channels are determined from voltage clamp experiments and usually involve the assumption that inactivation process occurs on a time scale which is infinitely slow compared to the(More)
A key aim of the cardiac Physiome Project is to develop theoretical models to simulate the functional behaviour of the heart under physiological and pathophysiological conditions. Heart function is critically dependent on the delivery of an adequate blood supply to the myocardium via the coronary vasculature. Key to this critical function of the coronary(More)
The aim of this study was to develop a novel method to reconstruct 3-D coronary vasculature from cryomicrotome images, comprised of two distinct sets of data-fluorescent microsphere beads and coronary vasculature. Fluorescent beads and cast injected into the vasculature were separately imaged with different filter settings to obtain the microsphere and(More)