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Premenopausal women have a lower cardiovascular risk and a higher incidence of several autoimmune diseases involving blood vessels than men. Although the precise effects of estrogens on the cardiovascular system are largely unknown, recent data suggest that estrogens can exert direct regulatory effects on endothelial cells. In the present study, we show(More)
Interactions between leucocytes and endothelial cells through specific adhesion receptors play an increasingly recognized crucial role in the development of inflammatory infiltrates in chronic inflammatory diseases. In this study we investigated adhesion molecule expression in muscle biopsies from 18 dermatomyositis, six polymyositis, five inclusion-body(More)
OBJECTIVE To investigate the expression pattern of adhesion molecules involved in leukocyte-endothelial cell interactions in giant cell arteritis (GCA). METHODS Immunohistochemical analysis was performed on frozen temporal artery sections from 32 patients with biopsy-proven GCA and from 12 control patients with other diseases. Adhesion molecules(More)
OBJECTIVE To investigate endothelial cell adhesion molecule expression in vessels from patients with classic polyarteritis nodosa (PAN). METHODS Frozen sections of 21 muscle and 16 nerve samples from 30 patients with biopsy-proven PAN and 12 histologically normal muscle and 2 histologically normal nerve samples from 12 controls were studied(More)
T-lymphocyte migration into tissues requires focal degradation of the basement membrane. In this study, we show that transient adherence to fibronectin induces the production of activated forms of matrix metalloproteinase-2 (MMP-2) and MMP-9, as well as downregulation of tissue inhibitor of metalloproteinase-2 (TIMP-2) by T-cell lines. MMP-2 activation was(More)
Splenic involvement is uncommon in patients with hydatid disease. The radiologic and clinical findings in nine patients with splenic hydatidosis are described. The three men and six women were 41-76 years old (mean, 58 years). Their histories and physical findings, the results of serologic tests for hydatidosis, and imaging procedures were evaluated. Plain(More)
Early steps of replication (penetration and uncoating) of the OSU strain of porcine rotavirus were studied in MA-104 cells. After adsorption of trypsin-treated viruses at 4 degrees, followed by a shifting of the temperature to 37 degrees, particles were seen within coated pits, coated vesicles, and secondary lysosomes, indicating that virus entry occurred(More)
OBJECTIVES To determine the difference in aspiration rates between gastrically and transpylorically fed patients in the intensive care unit. DESIGN A prospective controlled study of critically ill patients randomized to receive either a gastrically placed feeding tube or a transpylorically placed feeding tube. SETTING University teaching hospital's(More)
OBJECTIVES To investigate the prevalence and characteristics of antibodies to endothelial cells (aEC) from large vessel and from microvasculature in a group of patients with Behçet's disease (BD) to determine the relationship of these antibodies with clinical and laboratory features of the disease. METHODS Thirty patients with BD were prospectively and(More)