Jack E. Denham

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Citations60
Highly Influential Citations2
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Signatures of proprioceptive control in Caenorhabditis elegans locomotion
TLDR
A computational model is used to identify effects of neural and mechanical modulation on undulatory forward locomotion of Caenorhabditis elegans, with a focus on proprioceptively driven neural control, and reveals a fundamental relationship between body elasticity and environmental drag in determining the dynamics of the body.
Whole animal modeling: piecing together nematode locomotion
26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3
This work was produced as part of the activities of FAPESP Research, Disseminations and Innovation Center for Neuromathematics (grant 2013/07699-0, S. Paulo Research Foundation). NLK is supported…
Neuromechanical phase lag predicts material and neural control properties in Caenorhabditis elegans
TLDR
It is shown that sensory entrainment can suppress neuromechanical phase lag, that would otherwise emerge under centrally generated feed forward control, in C. elegans.
Inhibition underlies fast undulatory locomotion in C. elegans
TLDR
The shrinking phenotype is exhibited by wild-type as well as mutant animals in response to harsh touch to the head or tail, but only GABA transmission mutants show slow locomotion after stimulation, and inhibition is unnecessary for muscle alternation during slow undulation in either direction but crucial to sustain rapid dorsoventral alternation.
Inhibition Underlies Fast Undulatory Locomotion in Caenorhabditis elegans
TLDR
The experimental results suggest at least three non-mutually exclusive roles for inhibition that could underlie fast undulatory locomotion in C. elegans, which were tested with computational models: cross-inhibition or disinhibition of body-wall muscles, or neuronal reset.
Intrinsic and Extrinsic Modulation of C. elegans Locomotion
TLDR
An integrated neuromechanical computational model is used to study the combined effects of neural modulation, mechanical modulation and modulation of the external environments on undulatory forward locomotion in the nematode C. elegans.
Signatures of proprioceptive control in C. elegans locomotion
TLDR
A computational model is used to identify effects of neural and mechanical modulation on undulatory forward locomotion of C. elegans, with a focus on proprioceptively driven neural control, and reveals a fundamental relationship between body elasticity and environmental drag in determining the dynamics of the body.
Supplementary material from "Signatures of proprioceptive control in Caenorhabditis elegans locomotion"