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Giant-cell tumor of the bone (GCTB) is a rare neoplasm that affects young adults. The tumor is generally benign but sometimes can be locally aggressive. There are no standardized approaches to the treatment of GCTB. Recently, the RANKL inhibitor denosumab has shown activity in this tumor type. We present the case of a young female who presented with locally(More)
State-of-the-art decision tree methods apply heuristics recursively to create each split in isolation, which may not capture well the underlying characteristics of the dataset. The optimal decision tree problem attempts to resolve this by creating the entire decision tree at once to achieve global optimality. In the last 25 years, algorithmic advances in(More)
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