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Autotransport in Gram-negative bacteria denotes the ability of surface-localized proteins to cross the outer membrane (OM) autonomously. Autotransporters perform this task with the help of a β-barrel transmembrane domain localized in the OM. Different classes of autotransporters have been investigated in detail in recent years; classical monomeric but also(More)
Invasin and intimin are major virulence factors of enteropathogenic Yersiniae and Escherichia coli, mediating invasion into and intimate adherence to host cells, respectively. Several studies have hinted that extracellular portion of these homologous proteins might be exported via an autotransport mechanism, but rigorous experimental proof has been lacking.(More)
We recently published a paper in Molecular Immunology (Leo and Goldman, 2009) showing that the Eib proteins from certain E. coli strains bind IgG Fc, in contrast to a previous report (Ghumra and Pleass, 2007). Richard J. Pleass has commented on our paper (Pleass, 2009) and expressed a series of unjustified misgivings about our conclusions. Here, we address(More)
BACKGROUND Education is important in improving economies and creating literate, self-reliant and healthy societies. However, hunger is a barrier to basic education in Malawi. Hunger is also associated with a number of health risk behaviours, such as bullying, suicide ideation and unhygienic behaviours that may jeopardize the future of children. There are,(More)
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