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Alteration in Marrow Stromal Microenvironment and Apoptosis Mechanisms Involved in Aplastic Anemia: An Animal Model to Study the Possible Disease Pathology
Aplastic anemia (AA) is a heterogeneous disorder of bone marrow failure syndrome. Suggested mechanisms include a primary stem cell deficiency or defect, a secondary stem cell defect due to abnormalExpand
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Pesticide induced alterations in marrow physiology and depletion of stem and stromal progenitor population: An experimental model to study the toxic effects of pesticide
Long‐term exposure of agriculturally used organochloride and organophosphate pesticides have been shown to cause long‐lasting hematotoxicity and increased incidence of aplastic anemia in humans. TheExpand
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Pesticide induced marrow toxicity and effects on marrow cell population and on hematopoietic stroma.
Long term inhalation of toxic pesticides used for the domestic and industrial purposes have been shown to cause moderate to severe hematotoxicity and increased incidence of several marrowExpand
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Phenotypic alteration of limbal niche-associated limbal epithelial stem cell deficiency by ultraviolet-B exposure-induced phototoxicity in mice.
  • P. Das, J. Pereira, +5 authors S. Law
  • Biology, Medicine
  • Biochemistry and cell biology = Biochimie et…
  • 1 June 2013
Good vision requires a healthy cornea, and a healthy cornea needs healthy stem cells. Limbal epithelial stem cells (LESCs) are a traditional source of corneal epithelial cells and are recruited forExpand
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An animal model of chronic aplastic bone marrow failure following pesticide exposure in mice.
The wide use of pesticides for agriculture, domestic and industrial purposes and evaluation of their subsequent effect is of major concern for public health. Human exposure to these contaminantsExpand
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The bone marrow stem stromal imbalance--a key feature of disease progression in case of myelodysplastic mouse model.
Myelodysplastic syndromes (MDSs) represent a spectrum of disorders that are generally thought to arise from a defective hematopoietic stem cell leading to clonal, dysregulated hematopoiesis. AlthoughExpand
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Primitive Sca-1 Positive Bone Marrow HSC in Mouse Model of Aplastic Anemia: A Comparative Study through Flowcytometric Analysis and Scanning Electron Microscopy
Self-renewing Hematopoietic Stem Cells (HSCs) are responsible for reconstitution of all blood cell lineages. Sca-1 is the “stem cell antigen” marker used to identify the primitive murine HSCExpand
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Sca-1 / c-Kit receptor expression and apoptosis pattern in ENU induced MDS mice.
The bone marrow is the major site of haemopoiesis in adult human. It contains cells that represent the stages in the development of different types of blood cells e.g. myelocytes, metamyelocytes,Expand
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Kinetic impairment of haemopoietic stem cells in experimentally induced leukemia and aplastic anemia: an inverse correlation.
The production of blood cells from bone marrow (BM) hematopoietic stem cells (HSC) is regulated by a number of cytokines and growth factors that influence cell survival; differentiation,Expand
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Altered canonical hedgehog-gli signalling axis in pesticide-induced bone marrow aplasia mouse model
The mechanistic interplay between pesticide exposure and development of marrow aplasia is not yet well established but there are indices that chronic pesticide exposure in some instances causesExpand
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