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BACKGROUND We investigated treatment-related changes in oxidative stress indices in intrauterine growth retardation (IUGR) during pregnancy. Four parameters of cell membrane destruction were measured: malondialdehyde, Schiff bases, lipid peroxides, and conjugated dienes. MATERIAL/METHODS The study population included pregnant women under treatment in the(More)
UNLABELLED Intrauterine growth restriction is connected with high rate of prematurity and perinatal mortality. 8-isoprostane is one of the oxidative stress indices, similar to the prostaglandins and connected with vessels restriction. The main aim of the study was to find the correlation between the L-arginine and acetylsalicylic acid therapy and(More)
OBJECTIVES Carbonyl groups are the elements connecting protein structure, they influent into biological activity. High concentration of carbonyl groups means high risk of protein destruction. DESIGN The aim of this study was the evaluation of carbonyl group concentration in blood serum in normal pregnancy and in women with IUGR treated by L-arginine and(More)
UNLABELLED Elevated concentration of free radicals is observed in IUG and it is connected with high rate of prematurity and perinatal mortality too. The total antioxidative serum activity is one of the oxidative stress defence system parameter. The main aim of the study was to find the correlation between the L-arginine therapy and total antioxidative(More)
The tissue microarray (TMA) method currently is not used to render a primary diagnosis of cancer, but its scientific value has been proved in studies of various cancer types. TMA technology still is not used often for uterine tumors, however. We investigated the repeatability of histological diagnosis of endometrioid endometrial cancer (EEC) using(More)
OBJECTIVE There are numerous methods available of treating intrauterine growth restriction but their results are still not satisfactory. Currently, we are conducting a research project whose main aim is based on the use of the nitric oxide (NO) donor L-arginine in growth restriction therapy. The main aim of this study was the ultrasound evaluation of the(More)
OBJECTIVE To evaluate the safety and endometrial protection of low-dose transdermal estradiol (E2)/norethisterone acetate (NETA) patches (Estalis 25/125) in terms of post-treatment incidence of endometrial hyperplasia/cancer after 1 year of treatment in postmenopausal women with intact uteri. METHODS Patients were randomized to receive either transdermal(More)
INTRODUCTION Cancer antigen 125 (CA-125), known as a biomarker for women genital tract malignancies, could be also useful in detecting and monitoring endometriosis. The aim of this study was to evaluate CA-125 in serum and peritoneal fluid (PF) as an indicator of endometriosis. MATERIAL AND METHODS Fifty-six patients admitted to the First Department of(More)
The aim of the study was to develop an early ultrasound diagnostic schema for the determination of increased risk for fetal chromosomal aneuploidies. The study was conducted on a population of 1318 pregnant women divided into 2 groups: 1255 women with the normal course of pregnancy and 63 women with diagnosed fetal abnormalities. There were 34 cases of(More)
OBJECTIVES To assess the prognostic significance of Ki-67 expression in the tissue microarray method (TMA) for disease free survival (DFS) and overall survival (OS) in endometrioid endometrial cancer (EEC). MATERIAL AND METHODS The study examined 159 consecutive patients aged 37-86 (62.82 +/- 9.95) with EEC stages I-III according to FIGO, treated(More)