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We analyzed a list of the top 100 bestselling drugs as a struggling market for new FDA approvals. Using the time from drug approval by the FDA as a measure of drug age, our analysis showed that the top 100 bestselling drugs are getting older. This reflects the stalled launch of new drugs into the market during recent years.
Nature is among the world’s most highly cited multidisciplinary science journals with one of the highest impact factors of 38.597 (Nature Publishing Group (NPG) 2013), which is used relatively often in many scientific rankings. When analysing the regional distribution of Nature publications, we found a high correlation between the expenditures and the… (More)
Target-oriented drug discovery is the main research paradigm of contemporary drug discovery. In target-oriented approaches, we attempt to maximize in vitro drug potency by finding the optimal fit to the target. This can result in a higher molecular complexity, in particular, the higher molecular weight (MW) of the drugs. However, a comparison of the… (More)