Jacek A. Kopec

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Rheumatoid arthritis (RA) is a common, chronic disease where health-related quality of life (HRQL) is one of the main goals of therapy. As such, instruments used to measure HRQL in RA must be able to discriminate across RA severity. The two basic categories of instruments used to measure HRQL are generic instruments and disease-specific instruments. Generic(More)
PURPOSE To review the reliability and validity of the CAGE questionnaire across different patient populations and discuss its role in the detection of alcohol-related problems. METHODS The Cochrane Database for Systematic Reviews, Medline, Embase, and Psychinfo were searched. No systematic reviews were found on the Cochrane Database. Search of the other(More)
Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks(More)
OBJECTIVE To assess the reliability of physical examination of the osteoarthritic (OA) knee by rheumatologists, and to evaluate the benefits of standardization. METHODS Forty-two physical signs and techniques were evaluated using a 6 x 6 Latin square design. Patients with mild to severe knee OA, based on physical and radiographic signs, were examined in(More)
PURPOSE Sentinel lymph node resection (SNR) may reduce morbidity while providing the same clinical utility as conventional axillary dissection (AD). National Surgical Adjuvant Breast and Bowel Project (NSABP) B-32 is a randomized phase III trial comparing SNR immediately followed by AD (SNAD) to SNR and subsequent AD if SN is positive. We report the(More)
OBJECTIVE To evaluate 10 biomarkers in magnetic resonance imaging (MRI)-determined, pre-radiographically defined osteoarthritis (pre-ROA) and radiographically defined OA (ROA) in a population-based cohort of subjects with symptomatic knee pain. METHODS Two hundred one white subjects with knee pain, ages 40-79 years, were classified into OA subgroups(More)
The Quebec Back Pain Disability Scale is a new measure of functional disability for patients with back pain. Functional disability was operationalized in terms of perceived difficulty associated with simple physical activities. The content of the scale was developed in several stages, including a literature review, two studies seeking the opinions of(More)
Four generic, preference-weighted, health-related quality of life (HRQL) questionnaires (the Quality of Well-Being, the Health Utilities Index, the EQ-5D, and the SF-6D) are reviewed. Although all of these questionnaires are designed to measure the same concept, each uses a different model of health, a different method of deriving preferences, and a(More)
Background: Preference-based, generic measures are increasingly being used to measure quality of life and as sources for quality weights in the estimation of Quality Adjusted Life Years (QALYs) in rheumatoid arthritis (RA). However, among the most commonly used instruments (the Health Utilities Index 2 and 3 [HUI2 and HUI3], the EuroQoL-5D [EQ-5D], and the(More)
OBJECTIVES This article compares the impact of various self-reported chronic conditions on health-related quality of life, as measured by the Health Utilities Index 3 (HUI3), for the population aged 12 or older. DATA SOURCE The data are from the cross-sectional household component of the Health file of the 1996/97 National Population Health Survey. (More)