Jaap Hamburger

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A 74-year-old man was referred to our catheterization laboratory for elective angioplasty of the right coronary artery (RCA). One year earlier, he had suffered an acute inferior myocardial infarction, which was successfully treated with intravenous streptokinase. Only minor creatinine phosphokinase elevations were found. Since that time, however, the(More)
BACKGROUND On the basis of brachytherapy experience, edge stenosis has been raised as a potential limitation for drug-eluting stents. We used serial intravascular ultrasound (IVUS) to prospectively analyze vessel responses in adjacent reference segments after implantation of polymer-controlled paclitaxel-eluting stents. METHODS AND RESULTS TAXUS II was a(More)
Y oung women with acute coronary syndrome (ACS) frequently have nonatherosclerotic coronary artery disease (NACAD) and may be misdiagnosed. Coronary fibro-muscular dysplasia (CFMD) commonly is overlooked, as the angiographic appearance is often subtle. Our group previously described CFMD as a diffuse obliterative disease starting abruptly at the mid-distal(More)
Histamine production is greatly increased during culture of allograft recipient spleen cells in the presence of immunizing cells (secondary mixed leukocyte cultures [MLC]) as compared to that found in primary MLC (i.e., without previous allograft). This phenomenon appears after 24 h of culture and reaches its maximum at 48 h. Optimal increased histamine(More)
AIMS A randomized trial was performed to assess the safety and efficacy of a laser guidewire, in the treatment of chronic coronary occlusions. METHODS AND RESULTS In 18 European centres, 303 patients with a chronic coronary occlusion were randomized to treatment with either the laser guidewire (n=144) or conventional guidewires (mechanical guidewire,(More)
AIMS This study is the contribution by the Thoraxcenter, Rotterdam, to the European(32)P Dose Response Trial, a non-randomized multicentre trial to evaluate the safety and efficacy of the radioactive Isostent in patients with single coronary artery disease. METHODS AND RESULTS The radioactivity of the stent at implantation was 6--12 microCi. All patients(More)
BACKGROUND Rapid restoration of vessel patency after acute myocardial infarction is key to reducing myocardial muscle death and increases survival rates. Standard therapies include thrombolysis and direct PTCA. Alternative or adjunctive emergency therapies that could be initiated by minimally trained personnel in the field are of potential clinical benefit.(More)
A 60-year-old man was referred to our intervention laboratory for direct myocardial revascularization (DMR). He had received maximal medical therapy and had undergone coronary bypass surgery 10 years earlier, and his peripheral coronary anatomy was now found to be unsuited for surgical revascularization. In addition, the lesions on coronary angiog-raphy(More)
Water-deprived mice were injected with various concentrations of LiCl or NaCl 15 min before they were allowed to drink either water or 0.1% saccharin. The NaCl injections produced a dose-dependent increase in intake of both fluids: however, the higher dosages of LiCl produced a selective depression of fluid intakes. Saccharin intakes were depressed for less(More)
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