Jaakko Niinimäki

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The prevalence of “vertebral endplate signal changes” (VESC) and its association with low back pain (LBP) varies greatly between studies. This wide range in reported prevalence rates and associations with LBP could be explained by differences in the definitions of VESC, LBP, or study sample. The objectives of this systematic critical review were to(More)
STUDY DESIGN Cross-sectional comparison of self-reported low back pain (LBP) symptoms and Modic findings on magnetic resonance imaging (MRI). OBJECTIVES To investigate associations of frequency and intensity of LBP and sciatic pain with Modic changes in a sample of middle-aged male workers with or without whole-body vibration exposure. SUMMARY OF(More)
STUDY DESIGN A cross-sectional imaging study of young adults. OBJECTIVE To evaluate whether severity of low back symptoms predicts atrophy in the paraspinal muscles of young adults. SUMMARY OF BACKGROUND DATA Although an increased fat content of the lumbar muscles has been observed among adults with chronic LBP, there is limited knowledge of this(More)
STUDY DESIGN A longitudinal follow-up of Modic changes on magnetic resonance imaging (MRI). OBJECTIVES To assess the prevalence and natural course Modic changes over a 3-year follow-up period. SUMMARY OF BACKGROUND DATA Modic changes are bone marrow and endplate lesions visible on MRI. To the authors' knowledge, no follow-up studies on their natural(More)
STUDY DESIGN A cross-sectional magnetic resonance imaging study with questionnaires on low back pain (LBP) and functional limitations. OBJECTIVE To investigate the association between lumbar intervertebral disc degeneration (DD) and low back symptom severity among young Finnish adults. SUMMARY OF BACKGROUND DATA Both LBP and lumbar DD are common already(More)
STUDY DESIGN A cross-sectional genotype-phenotype evaluation. OBJECTIVE To evaluate the genetic background to Modic changes in an occupational cohort. SUMMARY OF BACKGROUND DATA Modic changes are vertebral endplate changes visible in magnetic resonance imaging. Twin studies suggest that intervertebral disc degeneration may be primarily explained by(More)
A decreased supply of nutrition to the intervertebral disc can lead to disc degeneration. Nutrient supply can be simulated in vivo by measuring gadolinium enhancement of the disc. We aimed to study the changes associated with disc degeneration that may have effect on the nutrition of the disc, i.e. lumbar artery narrowing, Modic changes, endplate defects,(More)
STUDY DESIGN An open-label study was conducted. OBJECTIVE To evaluate the efficacy and safety of infliximab, a monoclonal chimeric antibody, against tumor necrosis factor-alpha (TNFalpha) for the treatment of severe sciatica. SUMMARY OF BACKGROUND DATA Evidence from animal studies indicates that TNFalpha plays a role in the pathophysiology of sciatica.(More)
STUDY DESIGN A randomized controlled trial. OBJECTIVES To evaluate the long-term efficacy of infliximab, a monoclonal antibody against tumor necrosis factor alpha (TNF-alpha), in patients with acute/subacute sciatica secondary to herniated disc. SUMMARY OF BACKGROUND DATA The results of experimental studies and our open-label trial support the use of(More)
The value of apparent diffusion coefficient (ADC) measurements in intervertebral disc has been studied because ADC provides an estimate of free diffusion of unbound water and could be used as a quantitative tool to estimate degenerative changes. However, the challenging nature of diffusion imaging of spine and limited numbers of subjects in earlier studies(More)