• Publications
  • Influence
Development of a mitochondria-targeted Hsp90 inhibitor based on the crystal structures of human TRAP1.
  • C. Lee, H. Park, +11 authors B. Kang
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • 30 March 2015
The mitochondrial pool of Hsp90 and its mitochondrial paralogue, TRAP1, suppresses cell death and reprograms energy metabolism in cancer cells; therefore, Hsp90 and TRAP1 have been suggested asExpand
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Carbohydrate-coated nanocapsules from amphiphilic rod-coil molecule: binding to bacterial type 1 pili.
Stable carbohydrate-coated nanocapsules designed as multivalent nanoscaffolds for selective interactions with receptors are able to encapsulate guest molecules within their interior and to bindExpand
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Self-cross-linked polymer nanogels: a versatile nanoscopic drug delivery platform.
Nanoscopic vehicles that stably encapsulate drug molecules and release them in response to a specific trigger are of great interest due to implications in therapeutic applications, especially forExpand
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Cloaking nanoparticles with protein corona shield for targeted drug delivery
Targeted drug delivery using nanoparticles can minimize the side effects of conventional pharmaceutical agents and enhance their efficacy. However, translating nanoparticle-based agents into clinicalExpand
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Cancer-mitochondria-targeted photodynamic therapy with supramolecular assembly of HA and a water soluble NIR cyanine dye† †Electronic supplementary information (ESI) available. See DOI:
Herein, we introduce an indocyanine derivative (IR-Pyr) that is highly water soluble, exhibiting higher mitochondrial targetability and better photostability than IR-780.
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Synthesis and supramolecular nanostructure of amphiphilic rigid aromatic-flexible dendritic block molecules
We synthesized ABC triblock rigid aromatic-flexible dendritic block molecules consisting of a docosyl chain, rigid aromatic segment, and poly(ethylene oxide) dendrimer. These block molecules wereExpand
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Spatiotemporally and Sequentially-Controlled Drug Release from Polymer Gatekeeper–Hollow Silica Nanoparticles
Combination chemotherapy has become the primary strategy against cancer multidrug resistance; however, accomplishing optimal pharmacokinetic delivery of multiple drugs is still challenging. Herein,Expand
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Hyaluronic Acid-Modified Polymeric Gatekeepers on Biodegradable Mesoporous Silica Nanoparticles for Targeted Cancer Therapy
Systemic administration of mesoporous silica nanoparticles (MSNs) in biomedical applications has recently been questioned because of poor degradability, which is necessary for the successfulExpand
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MOF X Biopolymer: Collaborative Combination of Metal-Organic Framework and Biopolymer for Advanced Anticancer Therapy.
Metal-Organic Framework (MOFs) nanoparticles with high porosity and greater tunability have emerged as new drug delivery vehicles. However, premature drug release still remains a challenge in MOFExpand
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