JT Barr

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In a murine scrapie model, three different methods (immunohistochemistry, Western blotting and histoblotting) for determining disease-specific PrP accumulation were compared. The incubation period of ME7 scrapie in the F1 cross of C57 BL and VM/Dk mice is about 230 days. Mice show hippocampal neuronal loss from 160-180 days post-inoculation (dpi), CA1(More)
PURPOSE We compared the repeatability and accuracy of four commercially available videokeratography instruments and a manual keratometer. METHODS Ten optometry students and two university employees who had no history of rigid contact lens wear and no soft contact lens wear within 6 months of the study were measured. Two independent measurements were taken(More)
UNLABELLED PURPOSEBACKGROUND: Individuals with chronic ankle instability (CAI) often have impairments in ankle range of motion (ROM) and balance. There is limited evidence that these impairments are related in individuals with CAI. The purpose of this study was to determine the relationship between ankle dorsiflexion ROM and dynamic balance in individuals(More)
While surface electromyography (SEMG) can accurately register electrical activity of muscles during gait, there are no methods to estimate muscular force non-invasively. To better understand the mechanical behavior of muscle, we evaluated surface muscle pressure (SMP) in conjunction with SEMG. Changes in anterior thigh radial pressure during isometric(More)
Quantitative prediction of herb-drug interaction risk remains challenging. A quantitative framework to assess a potential interaction was used to evaluate a mechanism not previously tested in humans. The semipurified milk thistle product, silibinin, was selected as an exemplar herbal product inhibitor of raloxifene intestinal glucuronidation.(More)
Using gait analysis, we documented kinetic and temporospatial changes over a 7-year period in a single healthy individual with a transfemoral amputation walking with three different knees and matched foot components. The knee/foot pairs in chronological order were Four Bar Endolite knee/Endolite Dynamic Response foot; Ossur Total Knee 2000/Pathfinder I(More)
OBJECTIVE To determine changes in spinal reflex excitability of the soleus and fibularis longus muscles before and after fibular taping intervention. METHODS Twenty-one individuals (age = 23.4 ± 2.7 y, height = 171.0 ± 12.8 cm, mass = 69.7 ± 11.8 kg) with chronic ankle instability (CAI) and at least 5° ankle dorsiflexion asymmetry volunteered for this(More)
OBJECTIVES To determine the effects of fibular taping on ankle dorsiflexion range of motion (ROM) and dynamic balance in individuals with chronic ankle instability (CAI). DESIGN Single-blind, randomized crossover. METHODS Twenty-three individuals (age=23.4 ± 2.5 years, height=171.6 ± 12.4 cm, mass=71.5±13.1 kg) with CAI were allocated to either a(More)
Neurodegenerative pathology is typical of the transmissible spongiform encephalopathies (TSEs), and is thought to underlie clinical disease. Some morphometric studies have shown early focal neurone loss, but the full extent of TSE induced neuronal loss in the central nervous system is not known, and can only be accurately estimated using intensive(More)
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