JR Arribas

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OBJECTIVES The aim of this analysis was to review the evidence and update a meta-analysis evaluating the efficacy and safety results from randomized controlled trials of ritonavir-boosted protease inhibitor (PI/r) monotherapy. METHODS A PubMed/EMBASE search was conducted to find randomized trials of PI/r monotherapy vs. triple therapy in patients with(More)
Methods 333 HIV-1-infected adults on 3TC-containing triple regimens with <200 copies/mL for at least 6 months had their NRTI backbone randomly switched to either ABC/3TC or TDF/FTC. Pre-planned results at 1 year have been already published [2]. Treatment failure (defined as virological failure, discontinuation of study therapy, withdrawal of consent, lost(More)
Methods In the MONET trial, 256 patients with HIV RNA <50 copies/mL on current HAART, and no history of virological failure, switched to DRV/r 800/100 mg once daily, either as monotherapy (n=127) or with 2NRTI (n=129). HIV RNA was evaluated by the Roche Amplicor Ultrasensitive assay (lower detection limit=50 copies/mL), for all patient visits to Week 96.(More)
Methods In the MONET trial, 256 patients with no history of virological failure and HIV RNA <50 copies/mL on current HAART (NNRTI based (43%), or PI based (57%) switched to either DRV/r monotherapy (800/100 mg OD) versus DRV/r + 2NRTIs. HIV RNA levels were evaluated at Weeks 2, 12, 24, 36, 48, 60, 72, 84 and 96: all patient samples with HIV RNA above 50(More)
Methods In the MONET trial 256 patients with HIV RNA <50 copies/mL on current HAART for over 24 weeks (NNRTI based (43%), or PI based (57%)), switched to DRV/r 800/100 mg once daily, either as monotherapy (n=127) or with 2NRTI (n=129). The Spanish costs per patient with HIV RNA below 50 copies/mL were calculated, using a “switch included” analysis at Week(More)
OBJECTIVES PROTEA is a randomized controlled trial to assess the efficacy and safety of darunavir/ritonavir (DRV/r) monotherapy as an alternative to triple therapy. METHODS Patients fully suppressed on first-line antiretrovirals (viral load < 50 HIV-1 RNA copies/mL) were switched to DRV/r 800/100 mg once daily, either as monotherapy (n = 137) or with two(More)
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