JP Nkolola

  • Citations Per Year
Learn More
Background HIV-1 envelope glycoprotein is the primary target for HIV1-specific antibodies. The native HIV-1 envelope spike on the virion surface is a trimer, but trimeric gp140 and monomeric gp120 are currently believed to induce comparable immune responses. Indeed, most studies on the immunogenicity of HIV-1 envelope oligomers have revealed only marginal(More)
Background The generation of globally relevant HIV-1 immunogens mimicking native, trimeric Envelope (Env) structure, remains a major challenge for HIV-1 vaccine development. We identified a mosaic Env sequence, originally designed to optimize cellular immunologic coverage of global HIV-1 sequence diversity, which was capable of forming biochemically stable(More)
  • 1