JM Oliver

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We have shown previously that the beta-adrenergic agonist isoproterenol (2muM) and the phosphodiesterase inhibitor isobutylmethylxanthine (1 mM) produce a much greater increase in cyclic AMP in human leukocytes that have been pretreated with colchicine (or with other agents that affect microtubule assembly) than in control leukocytes. The effects of(More)
The Ch~diak-Higashi syndrome (CHS) is a rare disorder, characterized by giant granules in most granule-containing cells. Its major clinical expression is a marked susceptibility to pyogenic infections which, in the absence of defects in humoral or cellular immunity, has directed attention to polymorphonuclear leukocytes (PMNs). The properties of CHS PMNs(More)
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