JM Lancaster

Learn More
MicroRNA-155 (miR-155) is frequently upregulated in various types of human cancer; however, its role in cancer angiogenesis remains unknown. Here, we demonstrate the role of miR-155 in angiogenesis through targeting von Hippel-Lindau (VHL) tumour suppressor in breast cancer. Ectopic expression of miR-155 induced whereas knockdown of miR-155 inhibited human(More)
McKenna et al (March, 1995) used Southern analysis to identify a germline TaqI restriction fragment length polymorphism (RFLP) in intron G of the human progesterone receptor (hPR) defined by two alleles, TI and T2. The T2 allele contained an additional TaqI restriction site relative to TI, and was recently characterized as a 306 bp Alu element insertion and(More)
BACKGROUND Carboplatin and cisplatin, alone or in combination with paclitaxel, have similar efficacies against ovarian cancer (OVCA) yet exhibit different toxicity profiles. We characterised the common and unique cellular pathways that underlie OVCA response to these drugs and analyse whether they have a role in OVCA survival. METHODS Ovarian cancer cell(More)
Mutations in the BRCA1/BRCA2 genes account for varying proportions of breast cancer families studied, and demonstrate considerable variation in mutational spectra coincident with ethnic and geographical diversity. We have screened for mutations in 17 families from Wales with two or more cases of breast cancer under age 50 and/or ovarian cancer. Eight out of(More)
In recent years, the design of new antineoplastic agents that can halt the progression of human malignancies with minimal systemic damage has been at the forefront of cancer research, with cyclooxygenase-2 (COX-2) as a major target molecule. With an aim to demonstrate the expression and role of COX-2, the principal putative target of COX-2 inhibitor(More)
signatures in human cancers as a guide to targeted therapies. diffuse reflectance properties of malignant and benign breast tissues. Improvement in breast tumor discrimination by support vector machines and speckle-emphasis texture analysis. Automatic ultrasound segmentation and morphology based diagnosis of solid breast tumors.resolution aCGH and(More)
  • 1