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The antihypertensive activity of timolol, a new beta adrenergic blocking agent, was assessed in hypertensive patients. In hospitalized patients timolol, 5 mg orally every 8 hr for one week, resulted in a significant although mild reduction of blcod pressure with diastolic pressure falling from a mean of 101 mm Hg to 91 mm Hg. Heart rate and cardiac output(More)
Amiloride (AM), N-amidino-3,5,-diamino-6-chloropyrazinamide hydrochloride, induces natriuretic effects without potassium loss or rise in serum uric acid. 1 , 4 In single doses, AM has been shown to be less potent than hydrochlorothiazide (He); however, when administered daily in approximately maximal dosage, the natriuretic action of AM is sustained for a(More)
Carbamazepine is a widely prescribed antiepileptic drug. Owing to the lack of an intravenous formulation, its absolute bioavailability, absolute clearance, and half-life in patients at steady state have not been determined. We developed an intravenous, stable-labeled (SL) formulation in order to characterize carbamazepine pharmacokinetics in patients.(More)
Supported in part by Grants SMOI FR-42-06, SMOI FR-42-07, and STI HE-SS26-0S from the National Institutes of Health. Received for publication May 1, 1967. Our experimental design has been divided into three parts: (1) an acute study involving the administration of single doses of the drugs to normal subjects, (2) a six-day study in normal subjects, and (3)(More)
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