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Membrane targeting by the modern human immunodefi-ciency viruses is dependent on the plasma membrane-located phospholipid PI(4,5)P 2. In order to determine if evolutionarily distant retroviruses are targeted by a similar mechanism, we generated mutant Gag constructs in the matrix (MA) domain of the Murine Leukemia Virus (MuLV) and examined their binding to(More)
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