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We propose a class of two-sample non-parametric permutation tests to compare the marginal survival distributions of two groups when the failure times are correlated within cluster, with clusters nested within each group. The permutation distribution effectively takes into account the correlation between failure times within a cluster. The method is able to… (More)
BACKGROUND Relaxin (RLX) can prevent cardiac fibrosis. We aimed to investigate the possible mechanism and signal transduction pathway of RLX inhibiting cardiac fibrosis. METHODS Isoproterenol (5 mg·kg(-1)·d(-1)) was used to establish the cardiac fibrosis model in rats, which were administered RLX. The cardiac function, related targets of cardiac fibrosis,… (More)
We consider a latent variable hazard model for clustered survival data where clusters are a random sample from an underlying population. We allow interactions between the random cluster effect and covariates. We use a maximum pseudo-likelihood estimator to estimate the mean hazard ratio parameters. We propose a bootstrap sampling scheme to obtain an… (More)
This paper describes an approach for the analysis of barrier contraceptive efficacy trials that accounts for timing frequency of intercourse and compliance. We allow exposure variables to vary for each act of intercourse and we control for timing of each act through a specific parametric function of the day of the act relative to the last day of the… (More)
In the ACKNOWLEDGMENTS section of the article listed above, the sentence " C.L.C. received support from the Chang Gung Memorial Hospital (CMRPG34002) " should read as follows: " C.L.C. received support from the Chang Gung Memorial Hospital (CMRPG391151). " The online version reflects these changes.