JESISIS A. GARCIA-SEVILLA

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After twp weeks of twice-daily administration of amitriptyline to rats, the binding of [3H]clonidine to presynaptic a2-adrenoreceptors was decreased in membranes isolated from 5 areas of the rat brain. After one day of treatment, binding did not differ from saline treated controls. In vitro, a high concentration of amitriptyline caused a competitive(More)
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