JD Lifson

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Human interleukin 15 (IL-15) circulates in blood as a stable molecular complex with the soluble IL-15 receptor alpha (sIL-15Rα). This heterodimeric IL-15:sIL-15Rα complex (hetIL-15) shows therapeutic potential by promoting the growth, mobilization and activation of lymphocytes and is currently evaluated in clinical trials. Favorable pharmacokinetic(More)
Background: Many HIV databases and applications focus on a limited domain of HIV knowledge. Since even a ''simple'' organism like HIV represents a very complex system with many interacting elements, the fractured structure of existing databases and applications likely limits our ability to investigate and understand HIV. To facilitate research, therefore,(More)
T cell immune responses of HIV+ patients are functionally impaired prior to CD4+ T cell depletion. Tryptophan (trp) degradation by indoleamine-2, 3-dyoxigenase (IDO) is an immunosuppressive system that may be important in HIV/AIDS. We show here that IDO is increased in PBMC from HIV+ patients compared to controls. Culture with the IDO-inhibitor 1-methyl(More)
Though crystal structures for Env subunit fragments have been described, the overall structure of the Env spike and its distribution on virions has remained obscure. To address this issue, we have used cryoelectron microscopy (cryoEM) tomography to image unfixed and unstained HIV-1 and SIV virions in vitreous ice. Mutant (truncated TM tail) SIV virions show(More)
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