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Identification of a Peptide Toxin from Grammostola spatulata Spider Venom That Blocks Cation-Selective Stretch-Activated Channels
A 35 amino acid peptide toxin of the inhibitor cysteine knot family that blocks cationic stretch-activated ion channels is identified and implicates SACs in volume regulation.
Proinsulin conversion to desalanyl insulin by α2-macroglobin-bound trypsin
It is reported here that proinsulin, a large polypeptide of 9,000 molecular weight, is rapidly hydrolysed by α2-macroglobulin-bound trypsin, suggesting that pro-teases bound to α2 -macrogLobulin may be involved in limited proteolytic cleavage associated with activation of precursor molecules as well as the degradation of biologically active polypePTides in the circulation.
Plasma Immunoreactive Pancreatic Cationic Trypsinogen in Cystic Fibrosis: a Sensitive Indicator of Exocrine Pancreatic Dysfunction
The results suggest that in CF infants high levels of circulating trypsin(ogen) persist even in those with complete pancreatic insufficiency, and in older CF patients and those with Shwachman's syndrome, circulate accurately reflects residual pancreatic function.
Structural Basis for the Specific Activation of Human Cationic Trypsinogen by Human Enteropeptidase ”
It is proposed that the high degree of specificity for activation of human cationic trypsinogen by human enteropeptidase is due to the preferential recognition of the novel activation peptide sequence in the human zymogen.
Insecticidally effective peptide
The peptide obtained can be utilized as a new method for controlling invertebrate insect pests such as insects by transforming a gene in the venom and preparing a transformed plant having insecticidal actions.
Seed culture was prepared by transferring loopfuls of surface growth from an agar slant into 500ml Erlenmeyer flasks containing 100-ml portions of Nutrient medium composed of Tryptone 0.5 %, malt
Early Photoinduced Enzymes of Photoinduced
This is the first report of the photoinduction of enzymes acting prior to prephytoene pyrophosphate, and these enzymes are not restricted to carotene synthesis.