JAMES ASMUSSEN

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Conjunctival oxygen tension (PcjO2) and routine cardiorespiratory parameters were measured in 8 patients during pulmonary surgery. In each patient we found a close relationship between PcjO and arterial blood oxygen tension (PaO2), and for all patients the correlation coefficient was 0.962. The mean values of the ratio between PcjO2 and PaO2 in each patient(More)
Objective: The analgesic effect of codeine depends on its O-demethylation to morphine via sparteine oxygenase (CYP2D6) in the liver and presumably also via this enzyme in the CNS. We studied the ability of quinidine, which is a potent inhibitor of CYP2D6, to penetrate the blood brain barrier and its pssible impact on codeine O-demethylation in CNS. Methods:(More)
In 20 patients undergoing surgery for cerebral aneurysms, hypotension was induced with either gradual (over 5 min) or sudden increase of inspiratory concentration of isoflurane from 0.5% to 3%. Both modes elicited the same speed of induction of deliberate hypotension and similar decreases of cerebral arteriovenous difference of oxygen (AVDo2). The overall(More)
Twenty two patients were followed up for a mean of 10.7 years after acute yersinia arthritis. Their clinical course, agglutination antibodies, antibodies against plasmid coded yersinia proteins, and laboratory parameters of inflammation were analysed. The clinical findings were unremarkable. Serum agglutinating antibodies against Yersinia enterocolitica(More)
CAVHD and related techniques rely on vascular access to a large artery and a large vein with wide-bore catheters. The femoral vessels or a Scribner shunt are used most often. Bleeding, large retroperitoneal hematoma, arterio-venous fistula formation and infection are possible complications. We report our experience in 62 patients treated with CAVHD. Type of(More)
Twenty-two patients were followed for a mean of 10.7 years after acute Yersinia arthritis. Their clinical course, agglutinating antibodies, and laboratory parameters of inflammation were analyzed. In 73% of cases HLA-B27 was positive. The acute disease lasted from 1 month to 1 year. One male patient showed a bilateral synostosis of sacroiliac joints at the(More)
Sixteen patients with supratentorial cerebral tumours were subjected to craniotomy under thiopentone, fentanyl, nitrous oxide, halothane anaesthesia during moderate hypocapnia (PaCO2 level 4.0 kPa). The arterio-venous oxygen content difference (AVDO2) was measured peroperatively, and repeatedly during the first three hours after extubation. Peroperatively(More)
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