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Computer simulations were used to study the role of resistive couplings on flat-wave action potential propagation through a thin sheet of ventricular tissue. Unlike simulations using continuous or periodic structures, this unique electrical model includes random size cells with random spaced longitudinal and lateral connections to simulate the physiologic(More)
Theoretical simulations have suggested that interstitial potential (Vis) during action potential propagation affects measurements of the transmembrane action potential in bathed ventricular muscle. To evaluate the Vis experimentally, we obtained Vis and intracellular action potential (Vic) recordings at various depths in paced guinea pig papillary muscles(More)
Action potentials are voltage waveforms propagating along excitable tissues, such as neurons and cardiac myocytes. They are described by the " cable " equation, a parabolic diffusion-reaction PDE for the transmembrane potential, coupled to a system of ODEs for the ionic currents across the cell membrane, constituting the reaction term of the PDE. We present(More)
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