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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
TLDR
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Childhood Adversities Increase the Risk of Psychosis: A Meta-analysis of Patient-Control, Prospective- and Cross-sectional Cohort Studies
TLDR
It is shown that childhood adversity is strongly associated with increased risk for psychosis and population attributable risk was 33% (16%–47%).
Evidence that three dimensions of psychosis have a distribution in the general population
TLDR
The data suggest that the correlated dimensions of clinical psychosis also have a distribution in the general population, and that depressive symptoms may form an integral part of psychosis-like experiences in thegeneral population.
A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness–persistence–impairment model of psychotic disorder
TLDR
There is evidence, however, that transitory developmental expression of psychosis (psychosis proneness) may become abnormally persistent and subsequently clinically relevant (impairment), depending on the degree of environmental risk the person is additionally exposed to.
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
TLDR
It is estimated that 8,300 independent, mostly common SNPs contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability.
Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives
TLDR
Executive function and verbal memory are candidate bipolar endophenotypes given large deficits in these domains in bipolar patients and small, but intermediate, cognitive impairments in first-degree relatives.
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global
TLDR
The comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study 2015 was used to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational risks or clusters of risks from 1990 to 2015.
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
TLDR
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Validity and reliability of the CAPE: a self‐report instrument for the measurement of psychotic experiences in the general population
TLDR
This study tested the reliability and validity of the Community Assessment of Psychic Experiences (CAPE42) and demonstrated the prognostic validity of self‐reported psychotic experiences.
Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results
TLDR
Subthreshold self-reported psychotic experiences in epidemiological non-help-seeking samples index psychometric risk for psychotic disorder, with strong modifier effects of severity/persistence, can serve as the population reference for selected and variable samples of help-seeking individuals at ultra-high risk.
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