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The important role of stratum corneum lipids for the cutaneous barrier function.
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Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients[S]
TLDR
It is demonstrated for the first time that changes in ceramide chain length and lipid organization are directly correlated with the skin barrier defects in nonlesional skin of AE patients and will provide a new therapeutic entry in therapy and prevention of AE.
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Lamellar lipid organization and ceramide composition in the stratum corneum of patients with atopic eczema.
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Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients.
TLDR
Some major changes in epidermal lipid biosynthesis in patients with AD and other related skin diseases are discussed, and how inflammation has a deteriorating effect on the SC lipids and SC biosynthesis.
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TNF-α and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents.
TLDR
Results show that supplementation with TNF-α and Th2 cytokines influence epidermal morphogenesis and barrier function, and these LEMs show similar characteristics as found in AD skin and can be used as an excellent tool for screening formulations and drugs for the treatment of AD.
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LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery[S]
TLDR
A novel quick and robust LC/MS method is presented that allows the separation and analysis of all known human SC CER subclasses using only limited sample preparation and identifies one of these lipid subclasses as a new CER subclass: the ester-linked ω-hydroxy fatty acid with a dihydrosphingosine base.
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Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes.
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Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition.
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Glucocerebrosidase: Functions in and Beyond the Lysosome
TLDR
It has become apparent that GCase fulfills in the human body at least one other key function beyond lysosomes, and crucially, GCase generates ceramide molecules in the outer part of the skin, a process essential for optimal skin barrier property and survival.
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Increased presence of monounsaturated fatty acids in the stratum corneum of human skin equivalents.
TLDR
The HSEs have increased levels of ceramides EOS and EOH and ceramide species with short total carbon chains and a reduced FFA level compared with human SC, and the presence of unsaturated lipid chains in HSE offers new opportunities to mimic the lipid properties of human SC more closely.
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