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Play is indispensable for an adequate development of coping with social challenges in the rat.
- C. L. van den Berg, T. Hol, J. van Ree, B. M. Spruijt, H. Everts, J. Koolhaas
- Psychology, BiologyDevelopmental psychobiology
- 1 March 1999
The results suggest that early social experiences are vital for interactions with conspecifics later in life, i.e., aggression, sexual, and social interactions.
Pharmacokinetics and pharmacokinetic variability of heroin and its metabolites: review of the literature.
- E. J. Rook, A. Huitema, W. van den Brink, J. van Ree, J. Beijnen
- Medicine, BiologyCurrent clinical pharmacology
This article reviews the pharmacokinetics of heroin after intravenous, oral, intranasal, intramuscular and rectal application and after inhalation in humans, with a special focus on heroin…
Endogenous opioids and reward.
Medical prescription of heroin to treatment resistant heroin addicts: two randomised controlled trials
- W. van den Brink, V. Hendriks, P. Blanken, M. Koeter, B. J. van Zwieten, J. van Ree
- Medicine, PsychologyBMJ : British Medical Journal
- 7 August 2003
Supervised coprescription of heroin is feasible, more effective, and probably as safe as methadone alone in reducing the many physical, mental, and social problems of treatment resistant heroin addicts.
Intravenous self-administration of drugs in rats.
- J. van Ree, J. Slangen, D. de Wied
- Biology, MedicineThe Journal of pharmacology and experimental…
- 1 March 1978
The present results indicate that measuring the reinforcing efficacy of drugs under strictly defined experimental conditions provides quantitative criteria for intravenous self-administration of drugs in rats.
Pharmacokinetics and pharmacodynamics of high doses of pharmaceutically prepared heroin, by intravenous or by inhalation route in opioid-dependent patients.
Subjective heroin effect was rated more positively in heroin inhaling than in injecting patients, despite the lower C(max) levels following heroin inhalation, according to a pharmacokinetics and pharmacodynamics study performed in opioid-dependent patients in the Netherlands.
Opioids, reward and addiction: An encounter of biology, psychology, and medicine.
If the entire materia medica at our disposal were limited to the choice and use of only one drug, I am sure that a great many, if not the majority, of us would choose opium ([Macht, 1915]). ###…
Mu- and kappa-opioid receptor-mediated opioid effects on social play in juvenile rats.
- L. Vanderschuren, R. Niesink, B. M. Spruijt, J. van Ree
- Biology, PsychologyEuropean journal of pharmacology
Three studies suggest that the opioidergic effect on social play is mediated through mu- and kappa-opioid receptor systems, and the effects of receptor-specific opioid drugs on socialplay and measures of social behavior unrelated to play were investigated.
Low doses of oxytocin facilitate social recognition in rats
Low doses of oxytocin (OXT) given subcutaneously dose dependently facilitated social recognition of juveniles by adult male residents, and other neurohypophyseal hormones did not facilitate social recognition when tested in the same range of low doses.
The effects of low dose ketamine on sensory gating, neuroendocrine secretion and behavior in healthy human subjects
- B. V. van Berckel, B. Oranje, J. van Ree, M. Verbaten, R. Kahn
- Biology, PsychologyPsychopharmacology
- 26 June 1998
Although in humans NMDA receptors may not be involved in the regulation of PPI and P50 reduction, the most likely explanation for the lack of effect of ketamine on these sensory gating paradigms is the dose used in this experiment, which is hampered by the aspecificity of racemic ketamine.