• Publications
  • Influence
Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors.
R 41 468 is a potent antagonist of the vasoconstrictor effects of 5-hydroxytryptamine, in particular of its amplifying effect on threshold amounts of norepinephrine, which may help explain its antihypertensive properties. Expand
Antiarrhythmic, electrophysiologic and hemodynamic effects of lorcainide.
Studies in dogs show that lorcainide is effective against post-infarction and ouabain-induced ventricular arrhythmias, and abolishes acetylcholine and aconitine-induced atrial fibrillation; it elevates the threshold of electrically induced ventricular fibrilation. Expand
Comparative pharmacological profile of ritanserin and ketanserin
The effect of ritanserin was determined on a variety of isolated smooth muscle tissues. The compound is a potent antagonist of serotonin‐induced contractions of isolated blood vessels (IC50‐, Ah‐ orExpand
Serotonin and vascular reactivity.
Serotonin-induced vasoconstrictor responses may play a role in the etiology of vasospasm and peripheral vascular diseases, in particular at sites of endothelial lesions, and the platelet aggregation effects of serotonin combined with its accelerated turnover may be important in the induction and maintenance of the augmented peripheral vascular resistance in arterial hypertension. Expand
Interaction between 5-hydroxytryptamine and other vasoconstrictor substances in the isolated femoral artery of the rabbit; effect of ketanserin (R 41 468).
It is indicated that the interaction of 5-hydroxytryptamine with S2-receptors of the vascular smooth muscle cells is essential to allow the expression of the monoamine-induced amplification of the response to other vasoconstrictor substances. Expand
Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig.
The inhibition of gastric relaxation and the induction of colonic contractions in the presence of atropine indicate that, besides cholinergic neuronal pathways, other mechanisms are involved in the motor-stimulating properties of cisapride. Expand
Selectivity of Calcium Antagonism and Serotonin Antagonism with Respect to Venous and Arterial Tissues
This discussion will deal with two major aspects where arterial and venous smooth muscle differ in their sensitivity to vasoactive agents; theirensitivity to inhibitors of calcium-influx (Ca2+ antagonists) on the one hand and their reactivity to serotonin (5-hydroxytryptamine) and serotonin antagonists, on the other. Expand