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RPTPα is essential for NCAM-mediated p59fyn activation and neurite elongation
The neural cell adhesion molecule (NCAM) forms a complex with p59fyn kinase and activates it via a mechanism that has remained unknown. We show that the NCAM140 isoform directly interacts with theExpand
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Shp2 Knockdown and Noonan/LEOPARD Mutant Shp2–Induced Gastrulation Defects
Shp2 is a cytoplasmic protein-tyrosine phosphatase that is essential for normal development. Activating and inactivating mutations have been identified in humans to cause the related Noonan andExpand
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Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia
Loss-of-function mutations in pten genes, or expression of a constitutively active version of Akt2, render T-ALL cell survival and disease progression independent of Myc.
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A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality.
Breaking left-right symmetry in bilateria is a major event during embryo development that is required for asymmetric organ position, directional organ looping and lateralized organ function in theExpand
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Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS are being identified, but how theseExpand
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Regulation of receptor protein‐tyrosine phosphatase α by oxidative stress
The presence of two protein‐tyrosine phosphatase (PTP) domains is a striking feature in most transmembrane receptor PTPs (RPTPs). The function of the generally inactive membrane‐distal PTP domainExpand
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Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells.
BACKGROUND Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying molecular mechanisms remain poorlyExpand
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Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects
SUMMARY Noonan syndrome is a relatively common developmental disorder that is characterized by reduced growth, wide-set eyes and congenital heart defects. Noonan syndrome is associated withExpand
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Fyn/Yes and non‐canonical Wnt signalling converge on RhoA in vertebrate gastrulation cell movements
Convergent extension (CE) cell movements during gastrulation mediate extension of the anterior–posterior body axis of vertebrate embryos. Non‐canonical Wnt5 and Wnt11 signalling is essential forExpand
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Protein tyrosine phosphatase structure–function relationships in regulation and pathogenesis
Protein phosphorylation on tyrosine residues is tightly controlled by protein tyrosine phosphatases (PTPs) at multiple levels: spatio‐temporal expression, subcellular localization andExpand
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