• Publications
  • Influence
MDMA ('Ecstasy') enhances 5-HT1A receptor density and 8-OH-DPAT-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion.
TLDR
The present results indicate that drugs able to prevent or to attenuate MDMA-induced 5-HT loss also prevent the changes in5-HT1A receptor density as well as the enhanced hypothermic response to the 5- HT1A receptors agonist 8-OH-DPAT in MDMA-treated rats. Expand
The role of dopaminergic systems in the perinatal sensitivity to 3, 4-methylenedioxymethamphetamine-induced neurotoxicity in rats.
TLDR
The results appear to indicate that the hyperthermia induced by MDMA is not sufficient to produce lasting neurotoxic effects on the serotonergic system, at least at PND21, and support an important role for dopamine in the mechanism of neurotoxicity of MDMA. Expand
Effects of neonatal stress on markers of synaptic plasticity in the hippocampus: Implications for spatial memory
TLDR
It is suggested that MS can alter normal brain development, providing a potential mechanism by which early environmental stressors may influence vulnerability to show cognitive impairments later in life. Expand
Serotonin 5‐HT1A receptor expression is selectively enhanced in the striosomal compartment of chronic parkinsonian monkeys
TLDR
The results tend to support the possibility of an increased synthesis of 5‐HT1A receptors in brain regions with higher neuronal cell death, and may represent a compensatory event for the serotonergic dysfunction and associated mental disorders in neurodegenerative diseases such as Parkinson disease. Expand
Characterization of serotonergic mechanisms involved in the behavioural inhibition induced by 5-hydroxytryptophan in a modified light-dark test in mice.
TLDR
Even though different 5-HT receptor subtypes may be involved in the anxiogenic effect of a high dose of 5-hydroxytryptophan, postsynaptic 5- HT1A receptors appear to play a prominent role. Expand
Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model.
TLDR
In mice overexpressing mutant human amyloid precursor protein (hAPP), a model of AD, it is found that memory impairment in the object recognition test was prevented and also reversed by chronic rosiglitazone treatment. Expand
Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease.
TLDR
It is found that EphA4 and EphB2 receptors were reduced in the hippocampus before the development of impaired object recognition and spatial memory and changes in Eph-receptor downstream signaling that may cause cytoskeletal changes and disrupted synaptic activity are found. Expand
Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer's disease transgenic mice: an insight into the pathogenic effects of amyloid-β.
TLDR
It is found that VDAC1 is overexpressed in the hippocampus from amyloidogenic AD transgenic mice models, and regulation of the function of this channel may be a promising therapeutic approach to combat AD. Expand
Methylenedioxymethamphetamine induces opposite changes in central pre- and postsynaptic 5-HT1A receptors in rats.
TLDR
Both schedules of treatment reduced the serotonin content and [3H]paroxetine binding in the frontal cortex but not in the brain stem, and multiple but not single MDMA administration significantly reduced 5-HT1A receptor density in the selected brain stem region. Expand
Increased CRE-binding activity and tryptophan hydroxylase mRNA expression induced by 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rat frontal cortex but not in the hippocampus.
TLDR
In the frontal cortex, the increased TPH expression suggests a compensatory response to MDMA-induced loss of serotonergic function, and in the hippocampus, the decrease in TPH mRNA levels was found at all times, along with a reduced CRE-binding at the 8-h time point. Expand
...
1
2
3
4
5
...