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Effect of human chorionic gonadotrophin supplementation during different culture periods on in vitro maturation of canine oocytes.
The advancement of meiosis was directly proportional to the time of incubation; the highest percentage of oocytes at metaphase II was observed after 96 h of culture when 10 IU/mL hCG was present for only the first 48H of culture. Expand
Dermal absorption of polycyclic aromatic hydrocarbons in the blood‐perfused pig ear
The results of this study show that when pyrene is used as a marker compound for PAH absorption through pig skin, the cumulative absorption of PAHs with a lower molecular weight will be underestimated and it is likely that this conclusion is also valid for dermalPAH absorption in man. Expand
Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys.
HI-6 is an effective treatment against soman poisoning in marmosets and AChE reactivation or protection by HI-6 contributed to the survival of the animals. Expand
In vitro sperm penetration through the zona pellucida of immature and in vitro matured oocytes using fresh, chilled and frozen canine semen.
The aim of this study was to evaluate the effect of sperm cryopreservation and the maturation state of the oocyte on the time course of canine gamete interaction during co-culture for periods of 1-10 h and to determine the optimal incubation time in terms of maximizing penetration rates. Expand
In vitro degradation of the stereoisomers of soman in guinea-pig, mouse and human skin.
It is concluded that skin of the three species tested does not contain enzymes that degrade the toxic C(+/-)P(-)-isomers of soman, whereas phosphorylphosphatase activity for the C(+)P(+)-isomer is present in the skin of all three species. Expand
Bile acids and lipids in isolated rat hepatocytes: content, synthesis, and release, as affected by cholestyramine treatment of the donor rats.
Contents of bile acids and lipids, as well as rates of triglyceride synthesis, were determined in isolated hepatocytes from control or cholestyramine-fed rats (denoted below as "control" or "treated"Expand
Concomitant increase in hepatic triacylglycerol biosynthesis and cytosolic fatty-acid-binding-protein content after feeding rats with a cholestyramine-containing diet.
Cholestyramine feeding of rats increased the rate of palmitate and glycerol incorporation into triacylglycerols of isolated hepatocytes. Concomitantly an increase of fatty-acid binding by hepaticExpand
Effect of ML-236B (compactin) on biliary excretion of bile salts and lipids, and on bile flow, in the rat.
It is concluded that ML- 236B causes a transient bile salt-independent choleresis, ML-236B depresses excretion of bile salts and lipids by blocking mevalonate synthesis and not by blocking the bileSalt or lipid transport, and in rats with a prolonged total bile diversion newly formed meval onate is a major substrate for bile Salt synthesis. Expand
Bile acids and lipids in isolated rat hepatocytes. II. Source of cholesterol used for bile acid formation, estimated by incorporation of tritium from tritiated water, and by the effect of ML-236B.
It is concluded that in isolated hepatocytes newly made cholesterol can be a significant substrate for bile acid formation; there are separate cholesterol substrate pools for the productions of cholic or beta-muricholic acid; and of the total carbon flux directed into cholesterol synthesis, the major part ends up as free cholesterol and only a minor part as bile acids, even in hepatocytes with a derepressed bile Acid production. Expand
A water-soluble cholesteryl-containing trisgalactoside: synthesis, properties, and use in directing lipid-containing particles to the liver.
The synthesis of a trisgalactoside-terminated cholesterol derivative is described, which is coupled to cholesterol by using glycyl and succinyl as intermediate hydrophilic spacer moieties and dissolves easily in water, forming monodisperse micelles. Expand