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Copper radionuclides and radiopharmaceuticals in nuclear medicine.
Molecular imaging and biological evaluation of HuMV833 anti-VEGF antibody: implications for trial design of antiangiogenic antibodies.
TLDR
Because of the heterogeneity in tumor biology with respect to antibody uptake and clearance, it is suggested that either intrapatient dose escalation approaches or larger, more precisely defined patient cohorts would be preferable to conventional strategies in the design of phase I studies with antiangiogenic compounds like HuMV833.
One-pass list-mode EM algorithm for high-resolution 3-D PET image reconstruction into large arrays
TLDR
This work presents an algorithm which meets these demands: one-pass list-mode expectation maximization (OPL-EM) algorithm, which operates directly on list- mode data, passes through the data once only, accounts for finite resolution effects in the system model, and can also include regularization.
EM algorithm system modeling by image-space techniques for PET reconstruction
TLDR
The method demonstrates improved image quality in all cases when compared to the conventional FBP and EM methods presently used for clinical data (which do not include resolution modeling).
Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography.
TLDR
The ability to image the location (distribution) of gene expression and the level of expression over time provides new and useful information for monitoring clinical gene therapy protocols in the future.
A comparison of PET imaging characteristics of various copper radioisotopes
TLDR
The physical and radiochemical characteristics of the four copper isotopes make each more suited to some imaging tasks than others, and the results presented here assist in selecting the preferred radioisotope for a given imaging application.
The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression
TLDR
Using diverse tumor types, it is demonstrated that the BH4:BH2 ratio is lower in tumor tissues and, as a consequence, NOS activity generates more peroxynitrite and superoxide anion than nitric oxide, resulting in important tumor growth–promoting and antiapoptotic signaling properties.
Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival.
TLDR
It is concluded that Spag17 plays a critical role in the function and structure of motile cilia, and that neonatal lethality is likely explained by impaired airway mucociliary clearance.
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