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Secoverine selectively antagonizes muscarinic effects in various in vivo preparations.
Time-activity studies of secoverine and atropine were made with respect to mydriasis and oxotremorine-induced salivation, lacrimation and tremors. Marked differences were found in the anticholinergic… Expand
PHARMACOLOGICAL PROPERTIES OF MEBEVERINE, A SMOOTH-MUSCLE RELAXANT.
Pharmacology of secoverine, a new spasmolytic agent with specific antimuscarinic properties. Part 1: Antimuscarinic and spasmolytic effects.
1-Cyclohexyl-4-[ethyl(p-methoxy-alpha-methylphenethyl)amino]-1-butanone hydrochloride (secoverine hydrochloride) is a neurotropic spasmolytic agent with specific antimuscarinic properties. On the… Expand
Pharmacology of clovoxamine, a new non-tricyclic antidepressant.
Oxime ether derivatives, a new class of nonsteroidal antiinflammatory compounds.
A series of new 2-hydroxyethyl and carboxyalkyl ethers of aromatic oximes was found to possess pronounced antiinflammatory activity in the carrageenan-induced edema test in the rat. The activity was… Expand
Pharmacology of secoverine, a new spasmolytic agent with specific antimuscarinic properties. Part 2: General pharmacological properties.
The general pharmacological properties of 1-cyclohexyl-4-[ethyl(p-methoxy-alpha-methylphenethyl)amino]-1-butanone hydrochloride (secoverine hydrochloride), a neurotropic spasmolytic agent with… Expand
Differential effects of metoclopramide and zetidoline on gastrointestinal motility.
- M. Lobbezoo, F. Janszen, M. Tulp, J. Zwagemakers
- Chemistry, Medicine
- European journal of pharmacology
- 22 January 1985
There is a recently formulated hypothesis that metoclopramide (MCP) may stimulate gastrointestinal (GI) motility via an antagonistic action on presynaptic, release modulating muscarinic receptors. We… Expand
OXIME ETHER DERIVATIVES, A NEW CLASS OF NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS
219 – I SECOVERINE, A COMPOUND WITH SPECIFIC ANTIMUSCARINIC PROPERTIES