• Publications
  • Influence
Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain
TLDR
In vivo optogenetic techniques in awake, behaving mice are used to provide direct evidence that neuronal activity regulates changes in myelin-forming cells within an active circuit, suggesting that adaptive changes inMyelin-form cells represent a type of behaviorally relevant neural plasticity. Expand
p53-cofactor JMY is a Multifunctional Actin Nucleation Factor
TLDR
JMY represents a new class of multifunctional actin assembly factor whose activity is regulated, at least in part, by sequestration in the nucleus. Expand
CNS myelin wrapping is driven by actin disassembly.
TLDR
It is shown that myelin basic protein, a protein essential for CNS myelin wrapping whose role has been unclear, is required for actin disassembly, and its loss phenocopies loss of actindisassembly proteins are required for normal wrapping. Expand
Generation of oligodendroglial cells by direct lineage conversion
TLDR
The generation of induced OPCs (iOPCs) by direct lineage conversion was reported, which gave rise to mature oligodendrocytes that could ensheath multiple host axons when co-cultured with primary dorsal root ganglion cells and formed myelin after transplantation into shiverer mice. Expand
Type IV collagen is an activating ligand for the adhesion G protein–coupled receptor GPR126
TLDR
Type IV collagen is identified as an activating ligand for GPR126, its mechanism of activation is defined, and a previously unrecognized signaling function of type IV collagen in basement membranes is highlighted. Expand
Hts/Adducin Controls Synaptic Elaboration and Elimination
TLDR
It is demonstrated that Drosophila Hts/Adducin is enriched both pre- and postsynaptically at the NMJ, and it is proposed that phosphorylation-dependent regulation of Hts or Adducin controls the level, localization, and activity of HTS/Aducin, influencing actin-based synapse elaboration and spectrin-basedsynapse stabilization. Expand
Glia in mammalian development and disease
TLDR
The origins of glia are reviewed, their diverse roles during neural development and their contribution to plasticity and disease in the adult mammalian nervous system are discussed. Expand
Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury
TLDR
It is shown that Schwann cells, the myelinating glia of the PNS, collaborate with hematogenous macrophages to clear myelin debris using TAM (Tyro3,Axl, Mer) receptor-mediated phagocytosis as well as autophagy, adding a mechanism, Axl/Mertk-mediated myelin clearance, to the repertoire of cellular machinery used toclear myelin in the injured PNS. Expand
Actin binding to WH2 domains regulates nuclear import of the multifunctional actin regulator JMY
TLDR
This study demonstrates that nuclear translocation of JMY is controlled by the concentration of monomeric actin in the cytoplasm. Expand
DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells
TLDR
DeActs, genetically encoded actin-modifying polypeptides, are described, which effectively induce actin disassembly in eukaryotic cells and are demonstrated to be universal tools for studying the actin cytoskeleton in single cells in culture, tissues, and multicellular organisms including various neurodevelopmental model systems. Expand
...
1
2
3
...