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Human brain mechanisms of pain perception and regulation in health and disease
TLDR
This research highlights the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds. Expand
COMT val158met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor
TLDR
Individuals homozygous for themet158 allele of the catechol-O-methyltransferase (COMT) polymorphism showed diminished regional μ-opioid system responses to pain compared with heterozygotes, and these effects were accompanied by higher sensory and affective ratings of pain and a more negative internal affective state. Expand
Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors
TLDR
Cognitive factors (e.g., expectation of pain relief) are capable of modulating physical and emotional states through the site-specific activation of μ-opioid receptor signaling in the human brain. Expand
Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses.
TLDR
Placebo and nocebo effects are associated with opposite responses of DA and endogenous opioid neurotransmission in a distributed network of regions and form part of the circuit typically implicated in reward responses and motivated behavior. Expand
Cognitive function in euthymic Bipolar I Disorder
TLDR
Euthymic BDI patients demonstrate reductions in specific cognitive domains even after prolonged asymptomatic phases, some of these deficits appear to be associated with a more severe course of illness and poorer social and occupational functioning. Expand
Individual Differences in Reward Responding Explain Placebo-Induced Expectations and Effects
TLDR
The role of the nucleus accumbens (NAC), a region centrally involved in the encoding of reward expectation, in the formation of placebo responses was examined, and activation of NAC dopamine release was observed during placebo administration. Expand
Placebo effects on human μ-opioid activity during pain
TLDR
The results suggest that endogenous opioid release in core affective brain regions is an integral part of the mechanism whereby expectancies regulate affective and nociceptive circuits. Expand
Genetic variation in human NPY expression affects stress response and emotion
TLDR
It is shown that haplotype-driven NPY expression predicts brain responses to emotional and stress challenges and also inversely correlates with trait anxiety, consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress. Expand
BDNF Val66Met Allele Is Associated with Reduced Hippocampal Volume in Healthy Subjects
TLDR
The presence of the met-BDNF allele was found associated with a reduced volume of the hippocampal formation in healthy volunteers and may represent a vulnerability factor for the development of disease processes associated with the dysfunction of this brain region. Expand
Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain
TLDR
Sustained pain induced the regional release of endogenous opioids interacting with μ-opioid receptors in a number of cortical and subcortical brain regions, resulting in reductions in the sensory and affective ratings of the pain experience. Expand
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