• Publications
  • Influence
Mammalian cell protein expression for biopharmaceutical production.
  • J. Zhu
  • Medicine, Biology
  • Biotechnology advances
  • 1 September 2012
Mammalian cell expression has become the dominant recombinant protein production system for clinical applications because of its capacity for post-translational modification and human protein-likeExpand
  • 327
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Assessment of efficacy and safety of EUS-guided biliary drainage: a systematic review.
BACKGROUND AND AIMS EUS-guided biliary drainage (EUS-BD) has emerged as an alternative procedure after failed ERCP. However, limited data on the efficacy and safety of EUS-BD are available.Expand
  • 134
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The Coiled-coil Domain Is Required for HS1 to Bind to F-actin and Activate Arp2/3 Complex*
HS1 (hematopoietic lineage cell-specific protein 1), a substrate of protein tyrosine kinases in lymphocytes, binds to F-actin, and promotes Arp2/3 complex-mediated actin polymerization. However, theExpand
  • 57
  • 8
Regulation of cortactin/dynamin interaction by actin polymerization during the fission of clathrin-coated pits
Separation of clathrin-coated pits from the plasma membrane, a key event during endocytosis, is thought to be driven by dynamin and the actin cytoskeleton. However, the mechanism for theExpand
  • 82
  • 7
Differential regulation of cortactin and N-WASP-mediated actin polymerization by missing in metastasis (MIM) protein
Missing in metastasis (MIM) gene encodes an actin binding protein that is expressed at low levels in a subset of malignant cell lines. MIM protein tagged by green fluorescent protein (GFP)Expand
  • 87
  • 6
Niclosamide induced cell apoptosis via upregulation of ATF3 and activation of PERK in Hepatocellular carcinoma cells
BackgroundHepatocellular carcinoma (HCC) is one of most common and aggressive human malignancies in the world, especially, in eastern Asia, and its mortality is very high at any phase. We want toExpand
  • 20
  • 3
Receptor-mediated Endocytosis Involves Tyrosine Phosphorylation of Cortactin*
Efficient internalization of cell surface receptors requires actin polymerization mediated by Arp2/3 complex and cortactin, a prominent substrate of the protein-tyrosine kinase Src. However, theExpand
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Clinicopathological Significance of Overexpression of TSPAN1, KI67 and CD34 in Gastric Carcinoma
To investigate the expression of TSPAN1 (Gene ID: 10103), Ki67 and CD34 in gastric carcinomas and the clinicopathological significance, the expression of TSPAN1, Ki67 and CD34 was detected in 86Expand
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Production and purification of a recombinant Staphylococcal enterotoxin B vaccine candidate expressed in Escherichia coli.
An attenuated, recombinant form of Staphylococcus enterotoxin B (rSEB) was overexpressed in Escherichia coli under transcriptional control of the T7 promoter. The 28-kDa rSEB was partially purifiedExpand
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Down-regulation of HPV18 E6, E7, or VEGF expression attenuates malignant biological behavior of human cervical cancer cells
To investigate the effect of down-regulation of VEGF (vascular endothelial growth factor) and HPV18 E6/E7 by hairpin RNA (shRNA) on cell proliferation, apoptosis, migration, invasion, and adhesionExpand
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