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Keap1: one stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL.
Oxidative stress, implicated in the etiology of cancer, results from an imbalance in the production of Reactive Oxygen Species (ROS) and cell's own antioxidant defenses. As a oxidative stress sensor,… Expand
Regulation of the pituitary somatotroph cell by GHRH and its receptor.
- K. Mayo, T. Miller, V. Dealmeida, P. Godfrey, J. Zheng, S. R. Cunha
- Biology, Medicine
- Recent progress in hormone research
- 1 December 2000
Hormones from the hypothalamus mediate interactions between the nervous and endocrine systems by controlling the activity of specific target cells in the anterior pituitary gland. The hypothalamic… Expand
Aurora kinases: novel therapy targets in cancers
Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via regulating mitosis especially… Expand
Regulation of p53: a collaboration between Mdm2 and MdmX
p53 plays an important role in the regulation of the cell cycle, DNA repair, and apoptosis and is an attractive cancer therapeutic target. Mdm2 and Mdmx are recognized as the main p53 negative… Expand
DNA damage response--a double-edged sword in cancer prevention and cancer therapy.
Genomic stability depends on an efficient DNA damage repair system to keep the chromosomes intact. Unrepaired DNA damage not only causes cell cycle arrest, apoptosis, but also accumulates genome… Expand
RUNX3 Suppresses Migration, Invasion and Angiogenesis of Human Renal Cell Carcinoma
RUNX3 (runt-related transcription factor-3) is a known tumor suppressor gene which exhibits potent antitumor activity in several carcinomas. However, little is known about the role of RUNX3 in human… Expand
Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion.
The p53 transcription factor is a critical regulator of the cell cycle, DNA repair, and apoptosis. Recent evidences suggest that p53 may contribute to the regulation of cell invasion and migration.… Expand
BRG1 Is a Prognostic Marker and Potential Therapeutic Target in Human Breast Cancer
BRG1, a core component of the SWI/SNF chromatin-remodeling complex, has been implicated in cancer development; however, the biological significance of BRG1 in breast cancer remains unknown. We… Expand
A combination of humanised anti-CD19 and anti-BCMA CAR T cells in patients with relapsed or refractory multiple myeloma: a single-arm, phase 2 trial.
BACKGROUND Anti-B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T-cell therapy has been shown to have activity in patients with relapsed or refractory multiple myeloma. Reports have… Expand
SATB1 is overexpressed in metastatic prostate cancer and promotes prostate cancer cell growth and invasion
BackgroundSpecial AT-rich sequence binding protein 1 (SATB1) is a nuclear factor that functions as the global chromatin organizer to regulate chromatin structure and gene expression gene expression.… Expand