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Elution of Cationic Species with/without Ion Pair Reagents from Polar Stationary Phases via SFC
Traditionally, the application of supercritical fluid chromatography has been limited to compounds of relatively low polarity. Thus, we report here that one secondary amine and two quaternary amine
Feasibility of supercritical fluid chromatography/mass spectrometry of polypeptides with up to 40-mers.
TLDR
It is shown that relatively large peptides (at least 40 mers), containing a variety of acidic and basic residues, can be eluted in SFC, for the first time to the authors' knowledge.
Effects of ionic liquid on the separation of 2-chlorophenol and 2,4,6-trichlorophenol in RP-HPLC.
  • J. Zheng, K. Row
  • Chemistry, Medicine
    Journal of chromatographic science
  • 1 May 2009
TLDR
In this study, the use of ionic liquids as additives in the separation of 2-chlorophenol and 2,4,6-trichlorophenol in reversed-phase high-performance liquid chromatography is reported, with better resolution than with the [BF4] anion ionic liquid.
Determination of valproic acid and its metabolites using gas chromatography with mass-selective detection: application to serum and urine samples from sheep.
TLDR
An improved method for the quantitative determination of valproic acid (VPA) and sixteen of its metabolites has been developed using gas chromatography-mass spectrometry with selected-ion monitoring and appears to be equivalent in the sheep model.
Determination of 3-methylflavone-8-carboxylic acid, the main metabolite of flavoxate, in human urine by capillary electrophoresis with direct injection.
TLDR
By choosing the components of the eluent carefully, the free and conjugate forms of 3-methylflavone-8-carboxylic acid in human urine, the major metabolites of flavoxate could be simultaneously determined without pretreatment, using fenprofen as an internal standard.
Study of the elution mechanism of sodium aryl sulfonates on bare silica and a cyano bonded phase with methanol-modified carbon dioxide containing an ionic additive.
The elution mechanism of sodium sulfonates on both Deltabond cyanopropyl and bare silica stationary phases with an isocratic mobile phase composed of methanol-modified CO2 wherein an ammonium salt
Effect of ionic additives on the elution of sodium aryl sulfonates in supercritical fluid chromatography.
TLDR
The effect of various ionic additives on the elution of ionic compounds, such as Sodium 4-dodecylbenzene sulfonate and sodium 4-octylbenene sulfOnate, has been studied and successfully eluted using all the additives with good peak shape under isocratic/isobaric/isothermal conditions.
Effects of ionic liquid as additive and the pH of the mobile phase on the retention factors of amino benzoic acids in RP-HPLC.
TLDR
Three positional isomers of amino benzoic acid are separated with four different ionic liquids as additives to the mobile phase using reversed-phase (RP) high-performance liquid chromatography (HPLC) to study the effects of the length of the alkyl group on the imidazolium ring and its counterion.
Separation of Guanine and Hypoxanthine with Some Ionic Liquids in RP-HPLC
In this paper, guanine and hypoxanthine were separated with four different ionic liquids as additives for the mobile phase using reversed phase high performance liquid chromatography (RP-HPLC). The
Rapid Determination of 13 Sedative Substances and Their Metabolites in Blood by LC-MS/MS.
TLDR
This method is rapid, simple, effective and sensitive, and can be applied to analysis of 13 sedative substances and their metabolites in blood in forensic toxicology.