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G-Protein Signaling Through Tubby Proteins
It is shown that tubby functions in signal transduction from heterotrimeric GTP-binding protein (G protein)–coupled receptors, providing a direct link between G-protein signaling and the regulation of gene expression.
Cardiac troponin I phosphorylation increases the rate of cardiac muscle relaxation.
It is found that phosphorylation of a cardiac skinned muscle preparation by PKA results in a decrease in the Ca2+ sensitivity of muscle contraction, which can account for the faster relaxation seen in the inotropic response of the heart to catecholamines.
Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin.
Analysis of the CT deletion and point-mutation variants of gp600/megalin by the two-hybrid system revealed that the third PsiXNPXY motif is most probably involved in this interaction with Dab2, the first known transmembrane receptor that interacts with the cytosolic protein Dab 2.
PsaE Is Required for in Vivo Cyclic Electron Flow around Photosystem I in the Cyanobacterium Synechococcus sp. PCC 7002
It is concluded that, although PsaE is not required for linear electron flow to NADP+, it is an essential component in the cyclic electron transport pathway around photosystem I and there are three major electron sources for P700+ reduction in this cyanobacteria.
Cloning and characterization of the psaE gene of the cyanobacterium Synechococcus sp. PCC 7002: characterization of a psaE mutant and overproduction of the protein in Escherichia coli
The psaE gene, encoding a 7.5 kDa peripheral protein of the photosystem I complex, has been cloned and characterized from the cyanobacterium Synechococcus sp. PCC 7002. The gene is transcribed as an
Molecular Cloning of Human Plasma Membrane Phospholipid Scramblase
Quantitative immunoblotting revealed an approximately 10-fold higher abundance of PL scramblase in platelet than in erythrocyte, consistent with apparent increased PL scrambleblase activity of the platelet plasma membrane.
PsaD is required for the stable binding of PsaC to the photosystem I core protein of Synechococcus sp. PCC 6301.
The data indicate that although PsaC can bind loosely, the presence of PsaD leads to a stable, isolatable photosystem I complex which is spectroscopically indistinguishable from the native complex.
Functional calcium release channel formed by the carboxyl-terminal portion of ryanodine receptor.
The results show that the C-terminal portion of RyR contains structures sufficient to form a functional Ca2+ release channel, but the N-terminAL portion ofRyR also affects the ion-conduction and calcium-dependent regulation of the Ca2+, which inactivates at millimolar Ca2+.
Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy.
Changes in the Ca(2+) regulation of force development caused by these mutations would likely cause altered contractility and contribute to the development of FHC.
Characterization of psal and psaL Mutants of Synechococcus sp. Strain PCC 7002: A New Model for State Transitions in Cyanobacteria
The psal and psaL genes were characterized from the cyanobacterium Synechococcus sp. strain PCC 7002. The gene organization was different from that reported for other cyanobacteria with psal