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Tiotropium in Early‐Stage Chronic Obstructive Pulmonary Disease
Tiotropium resulted in a higher FEV1 than placebo at 24 months and ameliorated the annual decline in theFEV1 after bronchodilator use in patients with COPD of GOLD stage 1 or 2. Expand
Gallic acid
Anhydrous 3,4,5-trihydroxybenzoic acid, C7H6O5, is essentially planar, with its non-H atoms exhibiting mean and maximum deviations from coplanarity of 0.014 and 0.0377 (5) Å, respectively. TheExpand
Cassia cinnamon as a source of coumarin in cinnamon-flavored food and food supplements in the United States.
Coumarin and other marker compounds were analyzed in authenticated cinnamon bark samples as well as locally bought cinnamon samples, cinnamon-flavored foods, and cinnamon-based food supplements using a validated UPLC-UV/MS method and indicated that the cinnamon samples and the cinnamon in food supplements and flavored foods were probably Indonesian cassia, C. burmannii. Expand
Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF
This work suggests that KSR1 may function as a kinase, and it is anticipated that the mutation generated may be broadly applicable to stabilize the closed conformation of other kinases many of which may also form dimers. Expand
Metabolomic differentiation of maca (Lepidium meyenii) accessions cultivated under different conditions using NMR and chemometric analysis.
The results from both multivariate and univariate analysis indicated that the planting site was the major determining factor with regards to metabolite variations in maca hypocotyls, while the color of maca accession seems to be of minor importance in this respect. Expand
New alkamides from maca (Lepidium meyenii).
Five new alkamides have been found from only L. meyenii and could be used as markers for authentication and standardization and the identity of N-benzyl-15Z-tetracosenamide was confirmed by synthesis. Expand
Phytochemical investigation of Turnera diffusa.
A phytochemical investigation of Turnera diffusa afforded 35 compounds, comprised of flavonoids, terpenoids, saccharides, phenolics, and cyanogenic derivatives, including five new compounds (1-5) andExpand
Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads.
LC-mass spectrometry with electrospray ionization (ESI) interface method is described for the evaluation of ten compounds in plant samples and commercial products and indicated that the method is suitable as a quality control test for various Chamomile/Chrysanthemum samples and market products. Expand
Yellow tea (Camellia sinensis L.), a promising Chinese tea: Processing, chemical constituents and health benefits.
In this review, the history and classification of yellow tea are introduced, the processing procedures, including detailed information about "sealed yellowing", are presented, and the bioactive chemical compounds common in various types of teas or unique toyellow tea are discussed. Expand
Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans.
The structure-activity relationships of the dibenzocyclooctadiene lignans showed that the exocyclic methylene functionality was essential for antioxidant activity, with the benzoyloxy group probably enhancing such effects. Expand