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ABP1 Mediates Auxin Inhibition of Clathrin-Dependent Endocytosis in Arabidopsis
Spatial distribution of the plant hormone auxin regulates multiple aspects of plant development. These self-regulating auxin gradients are established by the action of PIN auxin transporters, whoseExpand
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Detection, causes and projection of climate change over China: An overview of recent progress
This article summarizes the main results and findings of studies conducted by Chinese scientists in the past five years. It is shown that observed climate change in China bears a strong similarityExpand
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Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts.
To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. StructuralExpand
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Genome sequence of the model medicinal mushroom Ganoderma lucidum
Ganoderma lucidum is a widely used medicinal macrofungus in traditional Chinese medicine that creates a diverse set of bioactive compounds. Here we report its 43.3-Mb genome, encoding 16,113Expand
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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening
Elucidation of the mutational landscape of human cancer has progressed rapidly and been accompanied by the development of therapeutics targeting mutant oncogenes. However, a comprehensive mapping ofExpand
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Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal.
Small, rapidly dividing pluripotent stem cells (PSCs) have unique energetic and biosynthetic demands compared with typically larger, quiescent differentiated cells. Shifts between glycolysis andExpand
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Structure of the human P2Y12 receptor in complex with an antithrombotic drug
P2Y receptors (P2YRs), a family of purinergic G-protein-coupled receptors (GPCRs), are activated by extracellular nucleotides. There are a total of eight distinct functional P2YRs expressed in human,Expand
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Mitochondrial genotype associated with longevity
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GJB2 mutation spectrum in 2063 Chinese patients with nonsyndromic hearing impairment
BackgroundMutations in GJB2 are the most common molecular defects responsible for autosomal recessive nonsyndromic hearing impairment (NSHI). The mutation spectra of this gene vary among differentExpand
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Widely accessible method for superresolution fluorescence imaging of living systems
Superresolution fluorescence microscopy overcomes the diffraction resolution barrier and allows the molecular intricacies of life to be revealed with greatly enhanced detail. However, many currentExpand
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