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The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.
The corepressors N-CoR and SMRT partner with histone deacetylases (HDACs) in diverse repression pathways. We report here that GPS2, a protein involved in intracellular signaling, is an integral… Expand
Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice.
Glutathione peroxidase and thioredoxin reductase are major selenoenzymes through which selenium exerts powerful antioxidant effects. Selenium also elicits pro-oxidant effects at toxic levels. The… Expand
Insights into salt tolerance from the genome of Thellungiella salsuginea
- Hua-Jun Wu, Zhonghui Zhang, +32 authors Qi Xie
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 9 July 2012
Thellungiella salsuginea, a close relative of Arabidopsis, represents an extremophile model for abiotic stress tolerance studies. We present the draft sequence of the T. salsuginea genome, assembled… Expand
E Protein Silencing by the Leukemogenic AML1-ETO Fusion Protein
The AML1-ETO fusion protein, generated by the t(8;21) chromosomal translocation, is causally involved in nearly 15% of acute myeloid leukemia (AML) cases. This study shows that AML1-ETO, as well as… Expand
Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice.
- J. Zhang, X. Wang, Tongwen Xu
- Medicine, Chemistry
- Toxicological sciences : an official journal of…
Selenium (Se) is an essential trace element with a narrow margin between beneficial and toxic effects. As a promising chemopreventive agent, its use requires consumption over the long term, so the… Expand
Mitochondrial generation of reactive oxygen species after brain ischemia in the rat.
BACKGROUND AND PURPOSE Brain mitochondria have a substantial capacity to generate reactive oxygen species after ischemia when the components of the respiratory chain are reduced and molecular oxygen… Expand
Comparison of short-term toxicity between Nano-Se and selenite in mice.
We previously reported that, as compared with selenite, nano red elemental selenium (Nano-Se) had lower acute toxicity in mice and similar bioavailability in terms of up-regulating seleno-enzymes.… Expand
Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling.
- J. Zhang, U. Vinkemeier, W. Gu, D. Chakravarti, C. Horvath, J. Darnell
- Proceedings of the National Academy of Sciences…
Interferon gamma (IFN-gamma) induces rapid tyrosine phosphorylation of the latent cytoplasmic transcription factor, Stat1, which then forms homodimers, translocates to the nucleus and participates in… Expand
Brain Temperature Alters Hydroxyl Radical Production during Cerebral Ischemia/Reperfusion in Rats
Selective neuronal cell death in the CA, pyramidal cells of the hippocampus and neurons of the dorsolateral striatum as a consequence of brain ischemia/reperfusion (IR) can be ameliorated with brain… Expand
Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate.
Among the protein kinases, an absolutely conserved lysine in subdomain II is required for high catalytic activity. This lysine is known to interact with the substrate ATP, but otherwise its role is… Expand