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Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia
The brain endothelium is an important therapeutic target for the inhibition of cerebrovascular dysfunction in ischemic stroke. Previously, we documented the important regulatory roles of microRNAs inExpand
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PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail
In Hedgehog (Hh) signaling, binding of Hh to the Patched-Interference Hh (Ptc-Ihog) receptor complex relieves Ptc inhibition on Smoothened (Smo). A longstanding question is how Ptc inhibits Smo andExpand
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The −590C/T polymorphism in the IL-4 gene and the risk of cancer: a meta-analysis
Interleukin-4 (IL-4) plays an important role in the pathogenesis of cancer. The −590C/T polymorphism in the IL-4 gene has been implicated in susceptibility to cancer, but the results have beenExpand
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HOXC8 promotes proliferation and migration through transcriptional up-regulation of TGFβ1 in non-small cell lung cancer
Homeobox (HOX) genes encode a family of transcription factors, which play crucial roles in numerous processes, and their dysregulation is involved in the carcinogenesis of many human cancers. In theExpand
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Norepinephrine induced epithelial–mesenchymal transition in HT-29 and A549 cells in vitro
PurposeNorepinephrine (NE) has been implicated in epithelial–mesenchymal transition (EMT) of cancer cells. However, the underlying mechanism is poorly understood. The goal of this study was toExpand
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AMPK Plays a Dual Role in Regulation of CREB/BDNF Pathway in Mouse Primary Hippocampal Cells
The hippocampus is vulnerable to damage under conditions of ischemia and hypoxia, causing multiple mental illnesses. cAMP response element-binding protein (CREB) plays a pivotal role in preventingExpand
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The pathophysiology of Fuchs' endothelial dystrophy--a review of molecular and cellular insights.
Fuchs' endothelial corneal dystrophy (FECD) is the most common corneal endothelial dystrophy and commonly results in loss of vision. This review highlights the advances in our understanding of theExpand
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Expression and genomic status of EGFR and ErbB-2 in alveolar and embryonal rhabdomyosarcoma
Both epidermal growth factor receptor (EGFR) and ErbB-2 play an important role in cancer biology and constitute promising molecular targets of therapy. EGFR and ErbB-2 expression has been observed inExpand
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Effects of terlipressin on patients with sepsis via improving tissue blood flow.
Terlipressin (TP), an analog of arginine vasopressin, was reported beneficial in sepsis patients when combined use with norepinephrine (NE), but the undetermined action, mechanism, and safety limitedExpand
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Critical Role of Mast Cell Chymase in Mouse Abdominal Aortic Aneurysm Formation
Background— Mast cell chymase may participate in the pathogenesis of human abdominal aortic aneurysm (AAA), yet a direct contribution of this serine protease to AAA formation remains unknown. MethodsExpand
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