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Programming and Inheritance of Parental DNA Methylomes in Mammals
The reprogramming of parental methylomes is essential for embryonic development. In mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted to oxidized bases. TheseExpand
The crystal structure of mouse VDAC1 at 2.3 Å resolution reveals mechanistic insights into metabolite gating
The voltage-dependent anion channel (VDAC) constitutes the major pathway for the entry and exit of metabolites across the outer membrane of the mitochondria and can serve as a scaffold for moleculesExpand
Diverse alternative back-splicing and alternative splicing landscape of circular RNAs.
Circular RNAs (circRNAs) derived from back-spliced exons have been widely identified as being co-expressed with their linear counterparts. A single gene locus can produce multiple circRNAs throughExpand
Thirty-One Flavors of Drosophila Rab Proteins
Rab proteins are small GTPases that play important roles in transport of vesicle cargo and recruitment, association of motor and other proteins with vesicles, and docking and fusion of vesicles atExpand
Rapid clearance of fetal DNA from maternal plasma.
Fetal DNA has been detected in maternal plasma during pregnancy. We investigated the clearance of circulating fetal DNA after delivery, using quantitative PCR analysis of the sex-determining region YExpand
Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos
5-methylcytosine is a major epigenetic modification that is sometimes called "the fifth nucleotide." However, our knowledge of how offspring inherit the DNA methylome from parents is limited. WeExpand
A Novel Cytokine Receptor-Ligand Pair
As part of a large scale effort to discover novel secreted proteins, a cDNA encoding a novel cytokine was identified. Alignments of the sequence of the new protein, designated IL-17B, suggest it toExpand
Human flavin-containing monooxygenases.
  • J. Cashman, J. Zhang
  • Chemistry, Medicine
  • Annual review of pharmacology and toxicology
  • 10 January 2006
This review summarizes recent information concerning the pharmacological and toxicological significance of the human flavin-containing monooxygenase (FMO, EC The human FMO oxygenatesExpand
Hidden dynamic allostery in a PDZ domain
Structure–function relationships in proteins are predicated on the spatial proximity of noncovalently interacting groups of atoms. Thus, structural elements located away from a protein's active siteExpand
Accumulation of cytoplasmic dynein and dynactin at microtubule plus ends in Aspergillus nidulans is kinesin dependent.
The mechanism(s) by which microtubule plus-end tracking proteins are targeted is unknown. In the filamentous fungus Aspergillus nidulans, both cytoplasmic dynein and NUDF, the homolog of the LIS1Expand