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Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors
DHE binds to 5-HT1B and 5- HT1D receptors up to 8-14 times longer than does sumatriptan, and prolonged binding to these receptors may be a mechanism for the sustained pain relief seen with DHE during the acute treatment of migraine.