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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
It is shown that the nuclear receptor CAR mediates the response evoked by a class of xenobiotics known as the ‘phenobarbital-like inducers’, and loss of CAR function alters sensitivity to toxins, increasing or decreasing it depending on the compound.
Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system.
A novel culture system is described that supports terminal fetal liver erythroblast proliferation and differentiation and that closely recapitulates erythroid development in vivo and shows that oncogenic H-ras blocks terminal erythyroid differentiation, but not through promoting apoptosis of terminally differentiated erystroid cells.
Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression.
In pituitary tumor cells, somatostatin analogues produce their antiproliferative action by acting on the PI3K/Akt signaling pathway and increasing Zac1 gene expression.
Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag
Pharmacological blockade of V1a and V1b in the SCN of wild-type mice resulted in accelerated recovery from jet lag, which highlights the potential of vasopressin signaling as a therapeutic target for management of circadian rhythm misalignment, such as jet lag and shift work.
Proinflammatory Profile Within the Grossly Normal Aged Human Aortic Wall
In the absence of lipid infiltration, the aged human aortic wall exhibits a proinflammatory profile that renders it a fertile substrate for the development of arterial disease, for example, atherosclerosis and hypertension.
miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia
The results uncover a previously unappreciated miRNA-regulation mechanism by which a single miRNA may target both oncogenes and tumour suppressors, simultaneously, or, sequentially, in tumourigenesis and normal development per cell differentiation, indicating that miRNA regulation is much more complex than previously thought.