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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
Organisms encounter a wide range of foreign compounds—or ‘xenobiotics’—with potentially harmful consequences. The cytochrome P450 (CYP) enzymes metabolize xenobiotics and thus are a primary defenceExpand
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Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system.
Ras signaling plays an important role in erythropoiesis. Its function has been extensively studied in erythroid and nonerythroid cell lines as well as in primary erythroblasts, but inconclusiveExpand
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Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag
Resetting the Circadian Clock Fatigue and other symptoms of jet lag arise when the body's internal circadian clock is out of sync with environmental light-dark cycles. Studying genetically modifiedExpand
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Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression.
Somatostatin limits cell growth by inhibiting the proliferative activity of growth factor receptors. In this study, it is shown that in pituitary tumor cells, the somatostatin analogue octreotideExpand
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O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.
Pharmacological ascorbate has been proposed as a potential anti-cancer agent when combined with radiation and chemotherapy. The anti-cancer effects of ascorbate are hypothesized to involve theExpand
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Human bone marrow stromal cell treatment improves neurological functional recovery in EAE mice
We investigated the treatment of remitting-relapsing experimental autoimmune encephalomyelitis (EAE) in mice with human bone marrow stromal cells (hBMSCs). hBMSCs were injected intravenously into EAEExpand
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SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.
Hypoxic stress and hypoxia-inducible factors (HIFs) play important roles in a wide range of tumors. We demonstrate that SPOP, which encodes an E3 ubiquitin ligase component, is a directExpand
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Proinflammatory Profile Within the Grossly Normal Aged Human Aortic Wall
Studies in animal models demonstrate that angiotensin II and its downstream signaling molecules, that is, matrix metalloproteinases and monocyte chemoattractant protein-1, increase within theExpand
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Estrogen receptor‐α36 is involved in development of acquired tamoxifen resistance via regulating the growth status switch in breast cancer cells
Acquired tamoxifen (TAM) resistance limits the therapeutic benefit of TAM in patients with hormone‐dependent breast cancer. The switch from estrogen‐dependent to growth factor‐dependent growth is aExpand
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Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling.
Naringenin, one of the most abundant flavonoids in citrus, grapefruits and tomatoes, has been used as a traditional anti-inflammatory agent for centuries. However, the molecular mechanism ofExpand
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